The conduct of interdisciplinary and translational clinical research is complex and can be optimizedthrough coordination of specialized resources across projects. This P30 will provide core Human Subjectsresources for coordinated and efficient data collection and statistical analysis across the clinical studies andpilot projects included in this consortium. Among the overall goals of the IRCSSA, is the need to study wellcharacterized clinical and non-clinical participants in all human projects so as to achieve both economics ofscale and more importantly to synthesize findings on stress, self control and addiction across multipleresponse systems. This may be achieved by a coordinated and centralized participant recruitment processand by the use of analogous measures to understand the key concepts of stress, self control and addictionacross research projects. Furthermore, as multi-system assessments (e.g., genetics, neurochemical,physiological, behavioral, social factors) are being conducted across studies, we plan to create largedatasets of common measures across clinical and non-clinical participant groups so as to evaluate the keyconstructs from multiple perspectives. In this way a Human Subjects P30 that incorporates these serviceswill enhance the synergy between human projects in the IRCSSA. Therefore, the overall aims of this Coreare the following: (1) To provide centralized coordination of subject recruitment for clinical studies; (2) Toprovide a central assessment resource on stress, self control, physical health screening measures and forspecific addictive behaviors of smoking, drinking, overeating; (3) To provide central data collection andmanagement resources; (4) To provide centralized and coordinated data analysis and statistics expertise;and (5) To provide scientific support and consultation to ongoing and pilot study investigators. Throughthese aims the P30 will provide critical support to the human studies and facilitate integration of data acrossprojects in the IRCSSA. Such integration will permit pooled analysis across studies that will lead to a morecomprehensive understanding of the stress mechanisms that affect self control processes in addiction.
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