Compounds with antiviral, antineoplastic, antifungal and antibacterial activities will be identified in marine species and their structures will be assigned. These include new components of the didemnin (antiviral, antineoplastic) and eudistomin (antiviral) complexes and an antineoplastic compound from Ecteinascidia turbinata, all from tunicates, as well as compounds from other tunicates and sponges. In addition, metabolites and quantitation of didemnin B will be studied in connection with its forthcoming clinical trials in cancer patients. Structures of a number of antibiotics will also be studied. These include the antifungal polyenes hamycin, aureofungin, and candimycin, as well as the non-polyenic antifungal macrolide desertomycin, the phospholipids quebemycin and 409 complex (antibacterial), the aromatic crisamicin (antineoplastic), and ficellomycin. Peptide antibiotics to be studied include saramycetin (antifungal), CC-1014B (cytotoxic), berninamycins A and B (antibacterial), antiamoebin, emerimicin, zervamicin, and alamethicin (all antibacterial and pore-forming). Bioactive compounds (antiviral) present in insects will also be identified and structural studies will be carried out on a Legionella pigment and a Pseudomonas growth factor.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI004769-28
Application #
3124205
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1977-05-01
Project End
1990-04-30
Budget Start
1989-05-01
Budget End
1990-04-30
Support Year
28
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
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Namikoshi, M; Yuan, M; Sivonen, K et al. (1998) Seven new microcystins possessing two L-glutamic acid units, isolated from Anabaena sp. strain 186. Chem Res Toxicol 11:143-9
Sakai, R; Rinehart, K L; Kishore, V et al. (1996) Structure--activity relationships of the didemnins. J Med Chem 39:2819-34
Sings, H L; Bible, K C; Rinehart, K L (1996) Acyl tunichlorins: a new class of nickel chlorins isolated from the Caribbean tunicate Trididemnum solidum. Proc Natl Acad Sci U S A 93:10560-5
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