Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI004769-33
Application #
2057750
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Project Start
1977-05-01
Project End
1996-04-30
Budget Start
1994-05-01
Budget End
1996-04-30
Support Year
33
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Yuan, M; Namikoshi, M; Otsuki, A et al. (1999) Low-energy collisionally activated decomposition and structural characterization of cyclic heptapeptide microcystins by electrospray ionization mass spectrometry. J Mass Spectrom 34:33-43
Namikoshi, M; Yuan, M; Sivonen, K et al. (1998) Seven new microcystins possessing two L-glutamic acid units, isolated from Anabaena sp. strain 186. Chem Res Toxicol 11:143-9
Sakai, R; Rinehart, K L; Kishore, V et al. (1996) Structure--activity relationships of the didemnins. J Med Chem 39:2819-34
Sings, H L; Bible, K C; Rinehart, K L (1996) Acyl tunichlorins: a new class of nickel chlorins isolated from the Caribbean tunicate Trididemnum solidum. Proc Natl Acad Sci U S A 93:10560-5
Sakai, R; Rinehart, K L (1995) A new polyether acid from a cold water marine sponge, a Phakellia species. J Nat Prod 58:773-7
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An, J; Carmichael, W W (1994) Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immunosorbent assay for the study of microcystins and nodularins. Toxicon 32:1495-507
Luukkainen, R; Namikoshi, M; Sivonen, K et al. (1994) Isolation and identification of 12 microcystins from four strains and two bloom samples of Microcystis spp.: structure of a new hepatotoxin. Toxicon 32:133-9
Guan, Y; Sakai, R; Rinehart, K L et al. (1993) Molecular and crystal structures of ecteinascidins: potent antitumor compounds from the Caribbean tunicate Ecteinascidia turbinata. J Biomol Struct Dyn 10:793-818
Namikoshi, M; Choi, B W; Sun, F et al. (1993) Chemical characterization and toxicity of dihydro derivatives of nodularin and microcystin-LR, potent cyanobacterial cyclic peptide hepatotoxins. Chem Res Toxicol 6:151-8

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