The overall objective of this research is to determine the role of differential initiation rates on mRNAs in regulating protein synthesis in normal, virus-infected, interferon treated and transformed cells. The significance of the inhibition of the rate of translation elongation in interferon-treated cells will be assessed, especially in regard to its possible selectivity against rapidly initiating (viral) mRNAs. The mechanism by which elongation inhibition is accomplished will also be studied. The intrinsic initiation rates on various viral and host mRNAs will be measured, and the factors which determine intrinsic initiation rate will be identified. Particular attention will be paid to the role of mRNA """"""""cap"""""""" structures, and cap-specific initiation factors.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI020484-15
Application #
3130181
Study Section
Virology Study Section (VR)
Project Start
1978-09-30
Project End
1988-07-31
Budget Start
1986-08-01
Budget End
1987-07-31
Support Year
15
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Washington University
Department
Type
Schools of Arts and Sciences
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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