Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI024083-09
Application #
2062448
Study Section
Microbial Physiology and Genetics Subcommittee 2 (MBC)
Project Start
1988-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Genetics
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655

  Publications

Wray, J W; Baase, W A; Lindstrom, J D et al. (1999) Structural analysis of a non-contiguous second-site revertant in T4 lysozyme shows that increasing the rigidity of a protein can enhance its stability. J Mol Biol 292:1111-20
Jucovic, M; Poteete, A R (1998) Delineation of an evolutionary salvage pathway by compensatory mutations of a defective lysozyme. Protein Sci 7:2200-9
Poteete, A R; Rennell, D; Bouvier, S E et al. (1997) Alteration of T4 lysozyme structure by second-site reversion of deleterious mutations. Protein Sci 6:2418-25
Bouvier, S E; Poteete, A R (1996) Second-site reversion of a structural defect in bacteriophage T4 lysozyme. FASEB J 10:159-63
Poteete, A R; Hardy, L W (1994) Genetic analysis of bacteriophage T4 lysozyme structure and function. J Bacteriol 176:6783-8
Rennell, D; Poteete, A R; Beaulieu, M et al. (1992) Critical functional role of the COOH-terminal ends of longitudinal hydrophobic strips in alpha-helices of T4 lysozyme. J Biol Chem 267:17748-52
Poteete, A R; Rennell, D; Bouvier, S E (1992) Functional significance of conserved amino acid residues. Proteins 13:38-40
Poteete, A R; Sun, D P; Nicholson, H et al. (1991) Second-site revertants of an inactive T4 lysozyme mutant restore activity by restructuring the active site cleft. Biochemistry 30:1425-32
Rennell, D; Bouvier, S E; Hardy, L W et al. (1991) Systematic mutation of bacteriophage T4 lysozyme. J Mol Biol 222:67-88
Casjens, S; Eppler, K; Parr, R et al. (1989) Nucleotide sequence of the bacteriophage P22 gene 19 to 3 region: identification of a new gene required for lysis. Virology 171:588-98