Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI033810-03
Application #
2068864
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1994-02-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Thomas Jefferson University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Zhang, H; Dornadula, G; Orenstein, J et al. (2000) Morphologic changes in human immunodeficiency virus type 1 virions secondary to intravirion reverse transcription: evidence indicating that reverse transcription may not take place within the intact viral core. J Hum Virol 3:165-72
Shaheen, F; Sison, A V; McIntosh, L et al. (1999) Analysis of HIV-1 in the cervicovaginal secretions and blood of pregnant and nonpregnant women. J Hum Virol 2:154-66
Zhang, H; Dornadula, G; Beumont, M et al. (1998) Human immunodeficiency virus type 1 in the semen of men receiving highly active antiretroviral therapy. N Engl J Med 339:1803-9
Dornadula, G; Zhang, H; Bagasra, O et al. (1997) Natural endogenous reverse transcription of simian immunodeficiency virus. Virology 227:260-7
Zhang, H; Dornadula, G; Pomerantz, R J (1996) Endogenous reverse transcription of human immunodeficiency virus type 1 in physiological microenviroments: an important stage for viral infection of nondividing cells. J Virol 70:2809-24
Zhang, H; Dornadula, G; Alur, P et al. (1996) Amphipathic domains in the C terminus of the transmembrane protein (gp41) permeabilize HIV-1 virions: a molecular mechanism underlying natural endogenous reverse transcription. Proc Natl Acad Sci U S A 93:12519-24
Zhang, H; Dornadula, G; Wu, Y et al. (1996) Kinetic analysis of intravirion reverse transcription in the blood plasma of human immunodeficiency virus type 1-infected individuals: direct assessment of resistance to reverse transcriptase inhibitors in vivo. J Virol 70:628-34
Zhu, M; Duan, L; Pomerantz, R J (1996) TAR- and Tat-independent replication of human immunodeficiency virus type 1 in human hepatoma cells. AIDS Res Hum Retroviruses 12:1093-101
Zhang, H; Duan, L X; Dornadula, G et al. (1995) Increasing transduction efficiency of recombinant murine retrovirus vectors by initiation of endogenous reverse transcription: potential utility for genetic therapies. J Virol 69:3929-32
Pomerantz, R J; Trono, D (1995) Genetic therapies for HIV infections: promise for the future. AIDS 9:985-93

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