Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034834-03
Application #
2070036
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1994-05-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Utah
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112

  Publications

Smith, Robert A; Anderson, Donovan J; Pyrak, Crystal L et al. (2009) Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance. J Infect Dis 199:1323-6
Smith, Robert A; Gottlieb, Geoffrey S; Anderson, Donovan J et al. (2008) Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro. Antimicrob Agents Chemother 52:329-32
Smith, Robert A; Anderson, Donovan J; Preston, Bradley D (2004) Purifying selection masks the mutational flexibility of HIV-1 reverse transcriptase. J Biol Chem 279:26726-34
Klarmann, George J; Chen, Xin; North, Thomas W et al. (2003) Incorporation of uracil into minus strand DNA affects the specificity of plus strand synthesis initiation during lentiviral reverse transcription. J Biol Chem 278:7902-9
Klarmann, G J; Smith, R A; Schinazi, R F et al. (2000) Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site. J Biol Chem 275:359-66
Smith, R A; Klarmann, G J; Stray, K M et al. (1999) A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine. Antimicrob Agents Chemother 43:2077-80
Klarmann, G J; Yu, H; Chen, X et al. (1997) Discontinuous plus-strand DNA synthesis in human immunodeficiency virus type 1-infected cells and in a partially reconstituted cell-free system. J Virol 71:9259-69
Preston, B D; Dougherty, J P (1996) Mechanisms of retroviral mutation. Trends Microbiol 4:16-21
Ji, X; Klarmann, G J; Preston, B D (1996) Effect of human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein on HIV-1 reverse transcriptase activity in vitro. Biochemistry 35:132-43
Preston, B D (1996) Error-prone retrotransposition: rime of the ancient mutators. Proc Natl Acad Sci U S A 93:7427-31