This is a competitive renewal to examine the biochemical and molecular determinants of variation in HIV. The experiments are organized into four specific aims.
The first aim i s to characterize mutations that arise in natural viral sequences rather than indicator sequences. The second is to determine whether vif, vpr, and nef affect mutation rate. The third is to assess the contribution of RT fidelity to mutation rate. The last aim is to determine the contribution of RNA pol II to mutation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI034834-06
Application #
6169892
Study Section
Special Emphasis Panel (ZRG1-AARR-1 (01))
Program Officer
Bridges, Sandra H
Project Start
1994-05-01
Project End
2003-07-31
Budget Start
2000-08-01
Budget End
2001-07-31
Support Year
6
Fiscal Year
2000
Total Cost
$282,976
Indirect Cost
Name
University of Utah
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
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