Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Research Project (R01)
Project #
5R01AI040482-07
Application #
6694058
Study Section
Experimental Virology Study Section (EVR)
Program Officer
Johnson, David R
Project Start
1997-01-01
Project End
2007-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
7
Fiscal Year
2004
Total Cost
$252,062
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Microbiology/Immun/Virology
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Byers, Nathaniel M; Vandergaast, Rianna L; Friesen, Paul D (2016) Baculovirus Inhibitor-of-Apoptosis Op-IAP3 Blocks Apoptosis by Interaction with and Stabilization of a Host Insect Cellular IAP. J Virol 90:533-44
Vandergaast, Rianna; Mitchell, Jonathan K; Byers, Nathaniel M et al. (2015) Insect inhibitor-of-apoptosis (IAP) proteins are negatively regulated by signal-induced N-terminal degrons absent within viral IAP proteins. J Virol 89:4481-93
Mitchell, Jonathan K; Byers, Nathaniel M; Friesen, Paul D (2013) Baculovirus F-box protein LEF-7 modifies the host DNA damage response to enhance virus multiplication. J Virol 87:12592-9
Taggart, David J; Mitchell, Jonathan K; Friesen, Paul D (2012) A conserved N-terminal domain mediates required DNA replication activities and phosphorylation of the transcriptional activator IE1 of Autographa californica multicapsid nucleopolyhedrovirus. J Virol 86:6575-85
Mitchell, Jonathan K; Friesen, Paul D (2012) Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication. J Virol 86:13542-53
Vandergaast, Rianna; Schultz, Kimberly L W; Cerio, Rebecca J et al. (2011) Active depletion of host cell inhibitor-of-apoptosis proteins triggers apoptosis upon baculovirus DNA replication. J Virol 85:8348-58
Cerio, Rebecca J; Vandergaast, Rianna; Friesen, Paul D (2010) Host insect inhibitor-of-apoptosis SfIAP functionally replaces baculovirus IAP but is differentially regulated by Its N-terminal leader. J Virol 84:11448-60
Schultz, Kimberly L W; Friesen, Paul D (2009) Baculovirus DNA replication-specific expression factors trigger apoptosis and shutoff of host protein synthesis during infection. J Virol 83:11123-32
Schultz, Kimberly L W; Wetter, Justin A; Fiore, Diccon C et al. (2009) Transactivator IE1 is required for baculovirus early replication events that trigger apoptosis in permissive and nonpermissive cells. J Virol 83:262-72
Guy, Michael P; Friesen, Paul D (2008) Reactive-site cleavage residues confer target specificity to baculovirus P49, a dimeric member of the P35 family of caspase inhibitors. J Virol 82:7504-14

Showing the most recent 10 out of 21 publications