Rhinitis is present in 70% of CFS subjects. The investigators have intensively studied the nasal mucosa in CFS rhinitis to evaluate three hypotheses of CFS pathology: (1) immune dysfunction with atopy; (2) mucosal inflammation including viral infections; They propose to prospectively analyze atopy, mucosal inflammation, and neural dysfunction in age- and sex-matched CFS and control groups by using integrated nasal analysis models. They feel strongly that their hypothesis-driven approach will precisely define specific neural pathophysiological mechanisms in CFS, allow pharmacological manipulation of these dysfunctional systems, and potentially lead to the development of simple new diagnostic tests (i.e. nasal provocation) as the means to evaluate future treatments of CFS.
| Ravindran, Murugan; Adewuyi, Oluwatoyin; Zheng, Yin et al. (2013) Dyspnea in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies. Glob J Health Sci 5:94-110 |
| Burbelo, Peter D; Bayat, Ahmad; Wagner, Jason et al. (2012) No serological evidence for a role of HHV-6 infection in chronic fatigue syndrome. Am J Transl Res 4:443-51 |
| Baraniuk, James N; Zheng, Yin (2010) Relationships among rhinitis, fibromyalgia, and chronic fatigue. Allergy Asthma Proc 31:169-78 |
| Baraniuk, James N; Jamieson, Mary J (2010) Rhinorrhea, cough and fatigue in patients taking sitagliptin. Allergy Asthma Clin Immunol 6:8 |
| Baraniuk, James N; Merck, Samantha J (2009) Neuroregulation of human nasal mucosa. Ann N Y Acad Sci 1170:604-9 |
| Baraniuk, James N; Casado, Begona; Malekzadeh, Sonya (2007) Differentiating osteomeatal complex disease and chronic rhinosinusitis from nonallergic rhinitis. Clin Allergy Immunol 19:115-46 |
| Kim, Dennis; Baraniuk, James N (2007) Sensing the air around us: the voltage-gated-like ion channel family. Curr Allergy Asthma Rep 7:85-92 |
| Stafford-Smith, Mark; Bartz, Raquel; Wilson, Katrina et al. (2007) Alpha-adrenergic mRNA subtype expression in the human nasal turbinate. Can J Anaesth 54:549-55 |
| Kim, Dennis; Baraniuk, James N (2007) Neural aspects of allergic rhinitis. Curr Opin Otolaryngol Head Neck Surg 15:268-73 |
| Baraniuk, James N; Ho Le, Uyenphuong (2007) The nonallergic rhinitis of chronic fatigue syndrome. Clin Allergy Immunol 19:427-47 |
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