Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37DK051996-21
Application #
9376975
Study Section
Special Emphasis Panel (NSS)
Program Officer
Haft, Carol R
Project Start
1997-01-01
Project End
2021-01-31
Budget Start
2017-03-01
Budget End
2018-01-31
Support Year
21
Fiscal Year
2017
Total Cost
$401,158
Indirect Cost
$126,158
Name
University of California San Diego
Department
Type
Domestic Higher Education
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wangeline, Margaret A; Hampton, Randolph Y (2018) ""Mallostery""-ligand-dependent protein misfolding enables physiological regulation by ERAD. J Biol Chem 293:14937-14950
Neal, Sonya; Jaeger, Philipp A; Duttke, Sascha H et al. (2018) The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Mol Cell 69:306-320.e4
Jaeger, Philipp A; Ornelas, Lilia; McElfresh, Cameron et al. (2018) Systematic Gene-to-Phenotype Arrays: A High-Throughput Technique for Molecular Phenotyping. Mol Cell 69:321-333.e3
Neal, Sonya; Mak, Raymond; Bennett, Eric J et al. (2017) A Cdc48 ""Retrochaperone"" Function Is Required for the Solubility of Retrotranslocated, Integral Membrane Endoplasmic Reticulum-associated Degradation (ERAD-M) Substrates. J Biol Chem 292:3112-3128
Wangeline, Margaret A; Vashistha, Nidhi; Hampton, Randolph Y (2017) Proteostatic Tactics in the Strategy of Sterol Regulation. Annu Rev Cell Dev Biol 33:467-489
Vashistha, Nidhi; Neal, Sonya E; Singh, Amanjot et al. (2016) Direct and essential function for Hrd3 in ER-associated degradation. Proc Natl Acad Sci U S A 113:5934-9
Higgins, ReneƩ; Gendron, Joshua M; Rising, Lisa et al. (2015) The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Mol Cell 59:35-49
Theesfeld, Chandra L; Hampton, Randolph Y (2013) Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. J Biol Chem 288:8519-30
Li, Shuyu; Spooner, Robert A; Hampton, Randolph Y et al. (2012) Cytosolic entry of Shiga-like toxin a chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p. PLoS One 7:e41119
Hampton, Randolph Y; Sommer, Thomas (2012) Finding the will and the way of ERAD substrate retrotranslocation. Curr Opin Cell Biol 24:460-6

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