Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA052791-05
Application #
2094987
Study Section
Pathology B Study Section (PTHB)
Project Start
1990-07-10
Project End
1997-06-30
Budget Start
1994-07-01
Budget End
1997-06-30
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Nelle, T D; Verderame, M F; Leis, J et al. (1998) The major site of phosphorylation within the Rous sarcoma virus MA protein is not required for replication. J Virol 72:1103-7
Verderame, M F (1997) pp60v-src transformation of rat cells but not chicken cells strongly correlates with low-affinity phosphopeptide binding by the SH2 domain. Mol Biol Cell 8:843-54
Verderame, M F; Nelle, T D; Wills, J W (1996) The membrane-binding domain of the Rous sarcoma virus Gag protein. J Virol 70:2664-8
Ignatoski, K M; Verderame, M F (1996) Lysis buffer composition dramatically affects extraction of phosphotyrosine-containing proteins. Biotechniques 20:794-6
Verderame, M F; Guan, J L; Woods Ignatoski, K M (1995) Transformation and pp60v-src autophosphorylation correlate with SHC-GRB2 complex formation in rat and chicken cells expressing host-range and kinase-active, transformation-defective alleles of v-src. Mol Biol Cell 6:953-66
Shao, H; Lou, L; Pandey, A et al. (1995) cDNA cloning and characterization of a Cek7 receptor protein-tyrosine kinase ligand that is identical to the ligand (ELF-1) for the Mek-4 and Sek receptor protein-tyrosine kinases. J Biol Chem 270:3467-70
Verderame, M F; Varmus, H E (1994) Highly conserved amino acids in the SH2 and catalytic domains of v-src are altered in naturally occurring, transformation-defective alleles. Oncogene 9:175-82
Siever, D A; Verderame, M F (1994) Identification of a complete Cek7 receptor protein tyrosine kinase coding sequence and cDNAs of alternatively spliced transcripts. Gene 148:219-26
Woods, K M; Verderame, M F (1994) Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src. J Virol 68:7267-74