Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Research Project (R01)
Project #
5R01CA063129-02
Application #
2104787
Study Section
Special Emphasis Panel (ZRG3-MEP (02))
Project Start
1995-09-30
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Pharmacology
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Liehr, J G (2001) Genotoxicity of the steroidal oestrogens oestrone and oestradiol: possible mechanism of uterine and mammary cancer development. Hum Reprod Update 7:273-81
Liehr, J G (2000) Is estradiol a genotoxic mutagenic carcinogen? Endocr Rev 21:40-54
Jefcoate, C R; Liehr, J G; Santen, R J et al. (2000) Tissue-specific synthesis and oxidative metabolism of estrogens. J Natl Cancer Inst Monogr :95-112
Kong, L Y; Szaniszlo, P; Albrecht, T et al. (2000) Frequency and molecular analysis of hprt mutations induced by estradiol in Chinese hamster V79 cells. Int J Oncol 17:1141-9
Kong, L Y; Hodgson, A V; Springer, I N et al. (1999) Lack of mutations in DNA polymerase beta of estradiol-induced hamster kidney tumors: sequence of hamster DNA polymerase beta cDNA. Int J Oncol 15:353-9
Roy, D; Liehr, J G (1999) Estrogen, DNA damage and mutations. Mutat Res 424:107-15
Sarabia, S F; Liehr, J G (1999) Differential regulation of c-fos expression in estrogen-induced hamster renal tumors compared with kidney not due to creation of an estrogen-response element by point mutation in the gene's flanking sequence. Mol Carcinog 24:255-62
Markides, C S; Roy, D; Liehr, J G (1998) Concentration dependence of prooxidant and antioxidant properties of catecholestrogens. Arch Biochem Biophys 360:105-12
Bhat, H K; Vadgama, J V; Liehr, J G (1998) Accumulation of albumin in renal cytosol of hamsters treated with estradiol and in estrogen-induced hamster kidney tumors. Int J Oncol 13:1087-91
Sarabia, S F; Liehr, J G (1998) Induction of monoamine oxidase B by 17 beta-estradiol in the hamster kidney preceding carcinogenesis. Arch Biochem Biophys 355:249-53

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