application): This proposal will investigate a new mode for treatment of periodontal diseases. Periodontal diseases comprise a group of related microbial-induced chronic inflammatory disorders that destroy the tissue supporting the teeth. The diseases can result in loss of normal soft and hard tissue architecture at sites adjacent to the affected teeth. The goals of this project are: to accelerate the recovery/restoration of new, healthy periodontal architecture; to reduce post-operative pain after periodontal surgery; and to reduce local pH to create an unfavorable environment for periodontic bacteria. The poly(anhydride-esters)(PAE's) described within are biodegradable (bioresorbable) materials that can be used for short-term dental treatments. The proposal is a demonstrator project for future applications in novel dental biomaterial technology. This system is the first example in which the polymer itself is a controlled-release system; the polymer membrane degrades into salicylic acid (SA), which has analgesic properties. The investigators anticipate that PAE's will simultaneously serve three purposes: accelerating the recovery/restoration of new, healthy periodontal architecture; reducing post-operative pain after periodontal surgery; and reducing local pH to create an unfavorable environment for periodontic bacteria. However, this Proposal focuses on what the investigators consider the most significant aspect of this novel degradable polymer-localized reduction of inflammation and restoration of healthy periodontal architecture. The goals of the proposal are to evaluate the ability of poly(anhydride-esters) to simultaneously reduce inflammation while restoring periodontal tissues. As a function of in vivo polymer degradation, the investigators address the following hypotheses: Does SA reduce the inflammatory response? Is SA observed systemically? Can the release of SA be controlled? Do the polymers restore healthy periodontal architecture? The overall objective of this proposal is to determine if the local delivery of SA via degradable PAE's will simultaneously reduce inflammation and restore healthy periodontal architecture.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Project (R01)
Project #
5R01DE013207-04
Application #
6606155
Study Section
Special Emphasis Panel (ZRG1-SSS-Z (01))
Program Officer
Kousvelari, Eleni
Project Start
2000-08-01
Project End
2004-06-30
Budget Start
2003-07-01
Budget End
2004-06-30
Support Year
4
Fiscal Year
2003
Total Cost
$161,372
Indirect Cost
Name
Rutgers University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Prudencio, Almudena; Faig, Jonathan J; Song, MinJung et al. (2016) Phenolic Acid-based Poly(anhydride-esters) as Antioxidant Biomaterials. Macromol Biosci 16:214-22
Yu, Weiling; Bien-Aime, Stephan; Mattos, Marcelo et al. (2016) Sustained, localized salicylic acid delivery enhances diabetic bone regeneration via prolonged mitigation of inflammation. J Biomed Mater Res A 104:2595-603
Lee, Yong S; Griffin, Jeremy; Masand, Shirley N et al. (2016) Salicylic acid-based poly(anhydride-ester) nerve guidance conduits: Impact of localized drug release on nerve regeneration. J Biomed Mater Res A 104:975-82
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Stebbins, Nicholas D; Ouimet, Michelle A; Uhrich, Kathryn E (2014) Antibiotic-containing polymers for localized, sustained drug delivery. Adv Drug Deliv Rev 78:77-87
Delgado-Rivera, Roberto; Rosario-Meléndez, Roselin; Yu, Weiling et al. (2014) Biodegradable salicylate-based poly(anhydride-ester) microspheres for controlled insulin delivery. J Biomed Mater Res A 102:2736-42
Rosario-Meléndez, Roselin; Yu, Weiling; Uhrich, Kathryn E (2013) Biodegradable polyesters containing ibuprofen and naproxen as pendant groups. Biomacromolecules 14:3542-8
Ouimet, Michelle A; Griffin, Jeremy; Carbone-Howell, Ashley L et al. (2013) Biodegradable ferulic acid-containing poly(anhydride-ester): degradation products with controlled release and sustained antioxidant activity. Biomacromolecules 14:854-61

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