Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK042155-03
Application #
3243190
Study Section
Pathology A Study Section (PTHA)
Project Start
1990-03-01
Project End
1992-06-30
Budget Start
1992-03-01
Budget End
1992-06-30
Support Year
3
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Kahn, D A; Archer, D C; Gold, D P et al. (2001) Adjuvant immunotherapy is dependent on inducible nitric oxide synthase. J Exp Med 193:1261-8
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Kahn, D A; Archer, D C; Kelly, C J (2000) Absence of functional inducible NO synthase enhances the efficacy of tolerance induced by high dose antigen feeding. J Immunol 165:6116-22
Satriano, J; Ishizuka, S; Archer, D C et al. (1999) Regulation of intracellular polyamine biosynthesis and transport by NO and cytokines TNF-alpha and IFN-gamma. Am J Physiol 276:C892-9
Satriano, J; Matsufuji, S; Murakami, Y et al. (1998) Agmatine suppresses proliferation by frameshift induction of antizyme and attenuation of cellular polyamine levels. J Biol Chem 273:15313-6
Gabbai, F B; Boggiano, C; Peter, T et al. (1997) Inhibition of inducible nitric oxide synthase intensifies injury and functional deterioration in autoimmune interstitial nephritis. J Immunol 159:6266-75
Bailey, N C; Kelly, C J (1997) Nephritogenic T cells use granzyme C as a cytotoxic mediator. Eur J Immunol 27:2302-9
Pham, K; Smoyer, W E; Archer, D C et al. (1997) Oral feeding of renal tubular antigen abrogates interstitial nephritis and renal failure in Brown Norway rats. Kidney Int 52:725-32
Bailey, N C; Frishberg, Y; Kelly, C J (1996) Loss of high affinity transforming growth factor-beta 1 (TGF-beta 1) binding to a nephritogenic T cell results in absence of growth inhibition by TGF-beta 1 and augmented nephritogenicity. J Immunol 156:3009-16
Frishberg, Y; Meyers, C M; Kelly, C J (1996) Cyclosporine A regulates T cell-epithelial cell adhesion by altering LFA-1 and ICAM-1 expression. Kidney Int 50:45-53

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