Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK043911-05
Application #
2143408
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1992-03-01
Project End
1998-03-31
Budget Start
1996-03-01
Budget End
1998-03-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Acevedo-Suarez, Carlos A; Hulbert, Chrys; Woodward, Emily J et al. (2005) Uncoupling of anergy from developmental arrest in anti-insulin B cells supports the development of autoimmune diabetes. J Immunol 174:827-33
Kendall, Peggy L; Woodward, Emily J; Hulbert, Chrys et al. (2004) Peritoneal B cells govern the outcome of diabetes in non-obese diabetic mice. Eur J Immunol 34:2387-95
Thomas, James W; Kendall, Peggy L; Mitchell, Holly G (2002) The natural autoantibody repertoire of nonobese diabetic mice is highly active. J Immunol 169:6617-24
Hulbert, C; Riseili, B; Rojas, M et al. (2001) B cell specificity contributes to the outcome of diabetes in nonobese diabetic mice. J Immunol 167:5535-8
Rojas, M; Hulbert, C; Thomas, J W (2001) Anergy and not clonal ignorance determines the fate of B cells that recognize a physiological autoantigen. J Immunol 166:3194-200
Tikhomirov, O Y; Thomas, J W (2000) Alanine scanning mutants of rat proinsulin I show functional diversity of anti-insulin monoclonal antibodies. J Immunol 165:3876-82
Thomas, J W; Kralick, P M; Ewulonu, U K (1997) T cell-independent response to Brucella-insulin identifies a preimmune repertoire for insulin. J Immunol 159:2334-41
Tikhomirov OYu; Thomas, J W (1997) Restricted V gene repertoire in the secondary response to insulin in young BALB/c mice. J Immunol 158:4292-300
Chapman, A; Stewart, S J; Nepom, G T et al. (1996) CD11b+CD28-CD4+ human T cells: activation requirements and association with HLA-DR alleles. J Immunol 157:4771-80
Thomas, J W; Hulbert, C (1996) Somatically mutated B cell pool provides precursors for insulin antibodies. J Immunol 157:763-71

Showing the most recent 10 out of 11 publications