Sexual impotence is a common male disorder affecting 10-12 million men) that can have great significance for health and health-care expenditures. Despite its prevalence, costs, and implications for quality of life impotence remains poorly understood in relation to the endocrine function, medication usage, lifestyles, anthropometrics and behavior (including alcohol consumption, smoking, and nutrition) in the susceptible populations of middle-aged and older men. No definitive population-based study of impotence has been conducted since, despite major changes since that time in social attitudes, possible new causes such as chemical hazards and clinical advances addressing impotence as a vascular disorder. An NIH Consensus Development Conference (1992) lamented the absence of epidemiologic studies of impotence and concluded there is an urgent need for work in this area. There are no normative data on male sexual functioning. The Massachusetts Male Aging Study (MMAS) in its baseline phase (t1, 1986- 90) assembled the largest population-based, cross-sectional database on male endocrine function, health status, sexual functioning, and psychosocial correlates available worldwide. Unique aspects of MMAS include * a random sample of free-living, apparently healthy men aged 38- 70; * a high yield (1709) of complete responses, permitting precise estimation of key parameters while controlling for confounders through subgroup analyses * a wide range of measures including sexual behavior, health status, medication usage, and physiologic, anthropometric, sociodemographic, and psychosocial variables comprehensive hormone, nutritional and lipid profiles; * an in-home protocol, including early- morning blood sampling and interviewer-administered instruments; * quality-control activities and validation substudies ensuring the high quality of the data. The proposed longitudinal follow-up is designed to examine two principal endpoints- impotence and hormone profiles - in the same MMAS subjects six years after the baseline study (t2, 1993-97) to address :(1) What was the incidence of impotence (new cases per year per 1000 men between t1 and t2? What changes occurred in the hormone profiles? (2) What was the relationship between the principal endpoints and the various classes of intervening variables, namely, sociodemographics; health status and medical care;psychosocial factors; and behavioral factors? Did the-cross- sectional relationship differ between t1 and t2? Did changes within subject in the intervening variables correlate with changes in hormones and impotence? (3) What is the prevalence of impotence (cases per 1000 men) in a normal population of free-living, apparently healthy men? The methods for data collection will be identical to those of the baseline MMAS. Trained technicians will recontact and re visit-the original MMAS sample (75 % are expected to be still available). The research proposed will provide the most comprehensive picture to date of impotence, hormones, and their physiological, psychosocial, and behavioral correlates in normal men.
| Hall, Susan A; Shackelton, Rebecca; Rosen, Raymond C et al. (2010) Risk factors for incident erectile dysfunction among community-dwelling men. J Sex Med 7:712-22 |
| Lakshman, Kishore M; Bhasin, Shalender; Araujo, Andre B (2010) Sex hormone-binding globulin as an independent predictor of incident type 2 diabetes mellitus in men. J Gerontol A Biol Sci Med Sci 65:503-9 |
| Travison, Thomas G; Shackelton, Rebecca; Araujo, Andre B et al. (2010) Frailty, serum androgens, and the CAG repeat polymorphism: results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 95:2746-54 |
| Hall, Susan A; Shackelton, Rebecca; Rosen, Raymond C et al. (2010) Sexual activity, erectile dysfunction, and incident cardiovascular events. Am J Cardiol 105:192-7 |
| Araujo, Andre B; Hall, Susan A; Ganz, Peter et al. (2010) Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score? J Am Coll Cardiol 55:350-6 |
| Araujo, Andre B; Travison, Thomas G; Ganz, Peter et al. (2009) Erectile dysfunction and mortality. J Sex Med 6:2445-54 |
| Travison, Thomas G; Shackelton, Rebecca; Araujo, Andre B et al. (2008) The natural history of symptomatic androgen deficiency in men: onset, progression, and spontaneous remission. J Am Geriatr Soc 56:831-9 |
| Page, Stephanie T; Mohr, Beth A; Link, Carol L et al. (2008) Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging Study. Asian J Androl 10:193-200 |
| Mohr, Beth A; Bhasin, Shalender; Kupelian, Varant et al. (2007) Testosterone, sex hormone-binding globulin, and frailty in older men. J Am Geriatr Soc 55:548-55 |
| Araujo, Andre B; Kupelian, Varant; Page, Stephanie T et al. (2007) Sex steroids and all-cause and cause-specific mortality in men. Arch Intern Med 167:1252-60 |
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