The Massachusetts Male Aging Study (MMAS) is considered a landmark research effort in the fields of aging, urology, and endocrinology. It employs a random sample of community-dwelling men (not a convenience sample of patient volunteers). Its size permits estimation of even relatively rare phenomena (e.g., hypogonadism). It is longitudinal (intra-subject variation) not cross-sectional (inter-subject variation) and has successfully followed a cohort from 987-89 (T1) through 1995-97 (T2). Worldwide, it remains the largest male endocrine database. It is the first and still the only major longitudinal study of ED. It is multidisciplinary. The MMAS team has been extraordinarily productive. Emphasis has been given to the practical clinical applications of scientific findings. The proposed project (""""""""EPIDEMIOLOGY OF HORMONES AND ERECTILE DYSFUNCTION IN AGING MEN"""""""") is designed to extend the highly productive MMAS by following a projected 800 already participating subjects through a third wave (T3). Building directly on earlier work we will: continue investigation of life-span changes in 14 carefully selected hormones in the same subjects; precisely delineate any hypogonadal syndrome and its major correlates; continue pioneering work on erectile dysfunction (ED) and its various predictors; precisely measure the hypothesized relation between ED (sentinel event) and subsequent CVD; extend knowledge concerning ED-related utilization behavior and quality of life in older men; and assess the validity of the single question measure of ED against a clinical urologic examination by a nationally-respected urologist blinded to subjects' self-reported ED status. Methods of data collection will be identical to those used previously for the MMAS. The proposed research will continue to provide the most comprehensive and reliable information available on ED, life-span hormonal changes and their physiological, psychosocial, anthropometric, and behavioral predictors in normally aging men. Prior to the MMAS there was: (a) no well-designed prospective study describing life span changes in endocrine functioning (hormones) in normally aging men; and (b) no definitive population-based study of ED and its biobehavioral correlates.
| Travison, Thomas G; Shackelton, Rebecca; Araujo, Andre B et al. (2010) Frailty, serum androgens, and the CAG repeat polymorphism: results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 95:2746-54 |
| Hall, Susan A; Shackelton, Rebecca; Rosen, Raymond C et al. (2010) Sexual activity, erectile dysfunction, and incident cardiovascular events. Am J Cardiol 105:192-7 |
| Araujo, Andre B; Hall, Susan A; Ganz, Peter et al. (2010) Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score? J Am Coll Cardiol 55:350-6 |
| Hall, Susan A; Shackelton, Rebecca; Rosen, Raymond C et al. (2010) Risk factors for incident erectile dysfunction among community-dwelling men. J Sex Med 7:712-22 |
| Lakshman, Kishore M; Bhasin, Shalender; Araujo, Andre B (2010) Sex hormone-binding globulin as an independent predictor of incident type 2 diabetes mellitus in men. J Gerontol A Biol Sci Med Sci 65:503-9 |
| Araujo, Andre B; Travison, Thomas G; Ganz, Peter et al. (2009) Erectile dysfunction and mortality. J Sex Med 6:2445-54 |
| Travison, Thomas G; Shackelton, Rebecca; Araujo, Andre B et al. (2008) The natural history of symptomatic androgen deficiency in men: onset, progression, and spontaneous remission. J Am Geriatr Soc 56:831-9 |
| Page, Stephanie T; Mohr, Beth A; Link, Carol L et al. (2008) Higher testosterone levels are associated with increased high-density lipoprotein cholesterol in men with cardiovascular disease: results from the Massachusetts Male Aging Study. Asian J Androl 10:193-200 |
| Mohr, Beth A; Bhasin, Shalender; Kupelian, Varant et al. (2007) Testosterone, sex hormone-binding globulin, and frailty in older men. J Am Geriatr Soc 55:548-55 |
| Araujo, Andre B; Kupelian, Varant; Page, Stephanie T et al. (2007) Sex steroids and all-cause and cause-specific mortality in men. Arch Intern Med 167:1252-60 |
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