Structure-Function Relationships of Human Glucokinase

Laporte, David C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Research Project (R01)
• Project #: 5R01DK046562-05
• Application #: 2145787
• Study Section: Biochemistry Study Section (BIO)
• Program Officer: Laughlin, Maren R
• Project Start: 1993-04-01
• Project End: 1998-06-30
• Budget Start: 1996-07-01
• Budget End: 1998-06-30
• Support Year: 5
• Fiscal Year: 1996

Institution

• Name: University of Minnesota Twin Cities
• Department: Biochemistry
• Type: Schools of Medicine
• DUNS #: 168559177
• City: Minneapolis
• State: MN
• Country: United States
• Zip Code: 55455

Publications

Miller, S P; Anand, G R; Karschnia, E J et al. (1999) Characterization of glucokinase mutations associated with maturity-onset diabetes of the young type 2 (MODY-2): different glucokinase defects lead to a common phenotype. Diabetes 48:1645-51

Argaud, D; Kirby, T L; Newgard, C B et al. (1997) Stimulation of glucose-6-phosphatase gene expression by glucose and fructose-2,6-bisphosphate. J Biol Chem 272:12854-61

Argaud, D; Zhang, Q; Pan, W et al. (1996) Regulation of rat liver glucose-6-phosphatase gene expression in different nutritional and hormonal states: gene structure and 5'-flanking sequence. Diabetes 45:1563-71

Xu, L Z; Harrison, R W; Weber, I T et al. (1995) Human beta-cell glucokinase. Dual role of Ser-151 in catalysis and hexose affinity. J Biol Chem 270:9939-46