Abstract

The Appropriate Blood Pressure Control in Diabetes (ABCD) Trial is a prospective, randomized clinical trial designed to ascertain the effects of moderate versus intensive therapy on the outcome of diabetic complications a normotensive and hypertensive population of type II diabetic subjects. F the purposes of the analyses, the normotensive and the hypertensive populations will be studied independently. The primary outcome measure is glomerular filtration rate (GFR). Secondary outcome measures include retinopathy, urinary albumin excretion (UAE), neuropathy and cardiovascular disease. The secondary aim of the study is to determine if the use of a calcium channel blocker (nisoldipine coat core) will confer equivalent benefits as an angiotensin converting enzyme (ACE) inhibitor (enalapril) wi regards to delaying the onset or diminishing the progression of type II diabetic complications. The trial is currently ongoing with the follow-up 950 randomized subjects. The proposal herein summarizes the design of the trial with the major emphasis on the design, management and operation of th Data Coordinating Center (DCC).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Project (R01)
Project #
5R01DK050298-02
Application #
2444156
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1996-07-01
Project End
1999-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Chacko, Karen M; Bauer, Timothy A; Dale, Rita A et al. (2008) Heart rate recovery predicts mortality and cardiovascular events in patients with type 2 diabetes. Med Sci Sports Exerc 40:288-95
Schrier, Robert W; Estacio, Raymond O; Mehler, Philip S et al. (2007) Appropriate blood pressure control in hypertensive and normotensive type 2 diabetes mellitus: a summary of the ABCD trial. Nat Clin Pract Nephrol 3:428-38
Nobakhthaghighi, Niloofar; Kamgar, Mohammed; Bekheirnia, Mir R et al. (2006) Relationship between urinary albumin excretion and left ventricular mass with mortality in patients with type 2 diabetes. Clin J Am Soc Nephrol 1:1187-90
Hockensmith, Melinda L; Estacio, Raymond O; Mehler, Philip et al. (2004) Albuminuria as a predictor of heart failure hospitalizations in patients with type 2 diabetes. J Card Fail 10:126-31
Mehler, Philip S; Coll, Joseph R; Estacio, Raymond et al. (2003) Intensive blood pressure control reduces the risk of cardiovascular events in patients with peripheral arterial disease and type 2 diabetes. Circulation 107:753-6
Mehler, Philip S; Esler, Anne; Estacio, Raymond O et al. (2003) Lack of improvement in the treatment of hyperlipidemia among patients with type 2 diabetes. Am J Med 114:377-82
Havranek, Edward P; Esler, Anne; Estacio, Raymond O et al. (2003) Differential effects of antihypertensive agents on electrocardiographic voltage: results from the Appropriate Blood Pressure Control in Diabetes (ABCD) trial. Am Heart J 145:993-8
Schrier, Robert W; Estacio, Raymond O; Esler, Anne et al. (2002) Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes. Kidney Int 61:1086-97
Cohen, J A; Jeffers, B W; Stabler, S et al. (2001) Increasing homocysteine levels and diabetic autonomic neuropathy. Auton Neurosci 87:268-73
Mehler, P S; Jeffers, B W; Biggerstaff, S L et al. (1998) Smoking as a risk factor for nephropathy in non-insulin-dependent diabetics. J Gen Intern Med 13:842-5

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