Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
8R01EB000226-02
Application #
6514472
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Korte, Brenda
Project Start
2001-07-01
Project End
2005-06-30
Budget Start
2002-07-01
Budget End
2003-06-30
Support Year
2
Fiscal Year
2002
Total Cost
$222,611
Indirect Cost

  Institution

Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045

  Publications

Kiptoo, Paul; Sinaga, Ernawati; Calcagno, Anna M et al. (2011) Enhancement of drug absorption through the blood-brain barrier and inhibition of intercellular tight junction resealing by E-cadherin peptides. Mol Pharm 8:239-49
Zheng, Kai; Laurence, Jennifer S; Kuczera, Krzysztof et al. (2009) Characterization of multiple stable conformers of the EC5 domain of E-cadherin and the interaction of EC5 with E-cadherin peptides. Chem Biol Drug Des 73:584-98
Zheng, Kai; Middaugh, C Russell; Siahaan, Teruna J (2009) Evaluation of the physical stability of the EC5 domain of E-cadherin: effects of pH, temperature, ionic strength, and disulfide bonds. J Pharm Sci 98:63-73
Trivedi, Maulik V; Laurence, Jennifer S; Siahaan, Teruna J (2009) The role of thiols and disulfides on protein stability. Curr Protein Pept Sci 10:614-25
Trivedi, Maulik; Davis, R Andrew; Shabaik, Yumna et al. (2009) The role of covalent dimerization on the physical and chemical stability of the EC1 domain of human E-cadherin. J Pharm Sci 98:3562-74
Dunehoo, Alison L; Anderson, Meagan; Majumdar, Sumit et al. (2006) Cell adhesion molecules for targeted drug delivery. J Pharm Sci 95:1856-72
Zheng, Kai; Trivedi, Maulik; Siahaan, Teruna J (2006) Structure and function of the intercellular junctions: barrier of paracellular drug delivery. Curr Pharm Des 12:2813-24
Calcagno, Anna Maria; Fostel, Jennifer M; Orchekowski, Randal P et al. (2005) Modulation of cell adhesion molecules in various epithelial cell lines after treatment with PP2. Mol Pharm 2:170-84
Huang, Meng; Matthews, Kametra; Siahaan, Teruna J et al. (2005) Alpha L-integrin I domain cyclic peptide antagonist selectively inhibits T cell adhesion to pancreatic islet microvascular endothelium. Am J Physiol Gastrointest Liver Physiol 288:G67-73
Anderson, Meagan E; Yakovleva, Tatyana; Hu, Yongbo et al. (2004) Inhibition of ICAM-1/LFA-1-mediated heterotypic T-cell adhesion to epithelial cells: design of ICAM-1 cyclic peptides. Bioorg Med Chem Lett 14:1399-402

Showing the most recent 10 out of 17 publications