? It has long been known that malignant tumors are often characterized by substantially different mechanical properties than surrounding normal tissue. This accounts for the efficacy of palpation as a clinical technique to detect cancer in accessible regions of the body. Indeed, most tumors of the thyroid, breast, and prostate are still first detected by this centuries-old diagnostic technique. Unfortunately, small or inaccessible lesions cannot be detected by touch, and conventional diagnostic imaging methods such as ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) do not provide information that is in any way analogous. The goal of this proposal is to continue to develop and validate a diagnostic imaging technique for quantitatively delineating mechanical properties of tissues. The technique applies mechanical waves to tissue and measures regional elasticity by analyzing the pattern of wave propagation. A critical component of this approach is sensitive MRI method for directly observing propagating acoustic waves in tissue, using an MRI sequence with synchronous motion-sensitizing gradients. The central hypothesis of this work is that the proposed technique can be successfully implemented as a practical scientific and clinical tool and that it will be useful for detecting and characterizing focal and diffuse disea.se processes that may be difficult to investigate by other methods. The research plan includes investigations in the following areas (1) improving the MR acoustic wave imaging technique, (2) developing effective methods for applying acoustic waves to tissue, (3) devising mathematical algorithms for processing the wave data, and (4) conducting pilot studies of selected applications of the new technology. The research plan in this continuation will again encompass theoretical work, basic MRI pulse sequence development, device engineering, studies of animal and human tissue specimens, and trials with normal and patient volunteers. Further progress is expected to provide an increasingly useful imaging tool with capabilities to: (1) noninvasively """"""""palpate by imaging"""""""" regions of the body that are beyond the reach of the physician's hand, (2) delineate tumors before they are large enough to detect by touch, (3) provide greater sensitivity for assessing changes in tissue elasticity, and (4) provide a useful new quantitative scientific tool for characterizing tissue. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
9R01EB001981-06
Application #
6610255
Study Section
Special Emphasis Panel (ZRG1-DMG (01))
Program Officer
Mclaughlin, Alan Charles
Project Start
1997-07-05
Project End
2008-05-31
Budget Start
2003-06-01
Budget End
2004-05-31
Support Year
6
Fiscal Year
2003
Total Cost
$365,000
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905
Yin, Ziying; Sui, Yi; Trzasko, Joshua D et al. (2018) In vivo characterization of 3D skull and brain motion during dynamic head vibration using magnetic resonance elastography. Magn Reson Med 80:2573-2585
Caussy, Cyrielle; Chen, Jun; Alquiraish, Mosab H et al. (2018) Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease. Clin Gastroenterol Hepatol 16:1974-1982.e7
Kellman, Michael; Rivest, Francois; Pechacek, Alina et al. (2018) Node-Pore Coded Coincidence Correction: Coulter Counters, Code Design, and Sparse Deconvolution. IEEE Sens J 18:3068-3079
Arunachalam, Shivaram P; Arani, Arvin; Baffour, Francis et al. (2018) Regional assessment of in vivo myocardial stiffness using 3D magnetic resonance elastography in a porcine model of myocardial infarction. Magn Reson Med 79:361-369
Cunha, Guilherme Moura; Glaser, Kevin J; Bergman, Anke et al. (2018) Feasibility and agreement of stiffness measurements using gradient-echo and spin-echo MR elastography sequences in unselected patients undergoing liver MRI. Br J Radiol 91:20180126
Arani, Arvin; Min, Hoon-Ki; Fattahi, Nikoo et al. (2018) Acute pressure changes in the brain are correlated with MR elastography stiffness measurements: initial feasibility in an in vivo large animal model. Magn Reson Med 79:1043-1051
Wang, Min; Gao, Feng; Wang, Xiaoqi et al. (2018) Magnetic resonance elastography and T1 mapping for early diagnosis and classification of chronic pancreatitis. J Magn Reson Imaging :
Pepin, K M; McGee, K P; Arani, A et al. (2018) MR Elastography Analysis of Glioma Stiffness and IDH1-Mutation Status. AJNR Am J Neuroradiol 39:31-36
Sui, Yi; Arunachalam, Shivaram P; Arani, Arvin et al. (2018) Cardiac MR elastography using reduced-FOV, single-shot, spin-echo EPI. Magn Reson Med 80:231-238
Ji, Ruoyun; Li, Jiahui; Yin, Ziying et al. (2018) Pancreatic stiffness response to an oral glucose load in obese adults measured by magnetic resonance elastography. Magn Reson Imaging 51:113-119

Showing the most recent 10 out of 163 publications