Abstract

The inhibitory neurotransmitter GABA has a central role in control and tuning of excitatory neuronal activity. GABA can be detected non-invasively using edited 1H magnetic resonance spectroscopy (MRS). Until now, this methodology has largely been confined to those sites that have local MRS expertise, and different implementations make comparison of results between site difficult. The overall goal of this grant is the development of a universal acquisition and processing pipeline for measuring GABA concentration in the human brain. We will develop a single sequence, implemented on all three major vendor platforms, for the macromolecule-suppressed GABA-edited MRS at 3T, the GABA Analysis Toolkit (Gannet) for quantitative data analysis, and demonstrate the cross-platform equivalence of the new measurement. The resulting data acquisition and analysis tools will be made available for dissemination to the clinical neuroscience and neuroimaging communities.

Public Health Relevance

GABA is a neurotransmitter, a chemical that is used for signaling in the brain that can be measured using MRI scanners, a technology that is of wide interest to researchers studying both healthy brain function and diseases of the brain. This project will develop new experimental and data processing tools for measuring GABA, reconcile the GABA values measured by existing techniques, and make this technology available to a large number of research sites worldwide.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Project (R01)
Project #
5R01EB016089-02
Application #
8708074
Study Section
(NOIT)
Program Officer
Liu, Guoying
Project Start
2013-08-01
Project End
2017-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Neurology
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Mikkelsen, Mark; Wodka, Ericka L; Mostofsky, Stewart H et al. (2018) Autism spectrum disorder in the scope of tactile processing. Dev Cogn Neurosci 29:140-150
Gao, Fei; Yin, Xuntao; Edden, Richard A E et al. (2018) Altered hippocampal GABA and glutamate levels and uncoupling from functional connectivity in multiple sclerosis. Hippocampus 28:813-823
Hermans, Lize; Leunissen, Inge; Pauwels, Lisa et al. (2018) Brain GABA Levels Are Associated with Inhibitory Control Deficits in Older Adults. J Neurosci 38:7844-7851
Deligiannidis, Kristina M; Fales, Christina L; Kroll-Desrosiers, Aimee R et al. (2018) Resting-state functional connectivity, cortical GABA, and neuroactive steroids in peripartum and peripartum depressed women: a functional magnetic imaging and resonance study. Neuropsychopharmacology :
Oeltzschner, Georg; Snoussi, Karim; Puts, Nicolaas A et al. (2018) Effects of eddy currents on selective spectral editing experiments at 3T. J Magn Reson Imaging 47:673-681
Cao, Guanmei; Edden, Richard A E; Gao, Fei et al. (2018) Reduced GABA levels correlate with cognitive impairment in patients with relapsing-remitting multiple sclerosis. Eur Radiol 28:1140-1148
Schallmo, Michael-Paul; Kale, Alexander M; Millin, Rachel et al. (2018) Suppression and facilitation of human neural responses. Elife 7:
Sanaei Nezhad, Faezeh; Anton, Adriana; Michou, Emilia et al. (2018) Quantification of GABA, glutamate and glutamine in a single measurement at 3 T using GABA-edited MEGA-PRESS. NMR Biomed 31:
Stivaros, Stavros; Garg, Shruti; Tziraki, Maria et al. (2018) Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA). Mol Autism 9:12
Saleh, Muhammad G; Mikkelsen, Mark; Oeltzschner, Georg et al. (2018) Simultaneous editing of GABA and glutathione at 7T using semi-LASER localization. Magn Reson Med 80:474-479

Showing the most recent 10 out of 68 publications