Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
5R01ES006361-03
Application #
2155224
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1994-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Washington
Department
Pediatrics
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Fantel, Alan G; Person, Richard E (2002) Involvement of mitochondria and other free radical sources in normal and abnormal fetal development. Ann N Y Acad Sci 959:424-33
Fantel, Alan G; Person, Richard E (2002) Further evidence for the role of free radicals in the limb teratogenicity of L-NAME. Teratology 66:24-32
Shepard, T H; Muffley, L A; Smith, L T (2000) Mitochondrial ultrastructure in embryos after implantation. Hum Reprod 15 Suppl 2:218-28
Person, R E; Chen, H; Fantel, A G et al. (2000) Enzymic catalysis of the accumulation of acetaldehyde from ethanol in human prenatal cephalic tissues: evaluation of the relative contributions of CYP2E1, alcohol dehydrogenase, and catalase/peroxidases. Alcohol Clin Exp Res 24:1433-42
Fantel, A G; Stamps, L D; Tran, T T et al. (1999) Role of free radicals in the limb teratogenicity of L-NAME (N(G)-nitro-(L)-arginine methyl ester): a new mechanistic model of vascular disruption. Teratology 60:151-60
Brzezinski, M R; Boutelet-Bochan, H; Person, R E et al. (1999) Catalytic activity and quantitation of cytochrome P-450 2E1 in prenatal human brain. J Pharmacol Exp Ther 289:1648-53
Chen, H; Brzezinski, M R; Fantel, A G et al. (1999) Catalysis of drug oxidation during embryogenesis in human hepatic tissues using imipramine as a model substrate. Drug Metab Dispos 27:1306-8
Shepard, T H; Muffley, L A; Smith, L T (1998) Ultrastructural study of mitochondria and their cristae in embryonic rats and primate (N. nemistrina). Anat Rec 252:383-92
Fantel, A G; Mackler, B; Stamps, L D et al. (1998) Reactive oxygen species and DNA oxidation in fetal rat tissues. Free Radic Biol Med 25:95-103
Mackler, B; Person, R E; Nguyen, T D et al. (1998) Studies of the cellular distribution of superoxide dismutases in adult and fetal rat tissues. Free Radic Res 28:125-9

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