Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
7R01ES006883-03
Application #
2018485
Study Section
Toxicology Subcommittee 2 (TOX)
Project Start
1994-09-01
Project End
1999-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Nukaya, Manabu; Walisser, Jacqueline A; Moran, Susan M et al. (2010) Aryl hydrocarbon receptor nuclear translocator in hepatocytes is required for aryl hydrocarbon receptor-mediated adaptive and toxic responses in liver. Toxicol Sci 118:554-63
Nukaya, Manabu; Lin, Bernice C; Glover, Edward et al. (2010) The aryl hydrocarbon receptor-interacting protein (AIP) is required for dioxin-induced hepatotoxicity but not for the induction of the Cyp1a1 and Cyp1a2 genes. J Biol Chem 285:35599-605
Lin, Bernice C; Nguyen, Linh P; Walisser, Jacqueline A et al. (2008) A hypomorphic allele of aryl hydrocarbon receptor-associated protein-9 produces a phenocopy of the AHR-null mouse. Mol Pharmacol 74:1367-71
Lin, Bernice C; Sullivan, Ruth; Lee, Youngsook et al. (2007) Deletion of the aryl hydrocarbon receptor-associated protein 9 leads to cardiac malformation and embryonic lethality. J Biol Chem 282:35924-32
Thomae, Tami L; Stevens, Emily A; Liss, Adam L et al. (2006) The teratogenic sensitivity to 2,3,7,8-tetrachlorodibenzo-p-dioxin is modified by a locus on mouse chromosome 3. Mol Pharmacol 69:770-5
Walisser, Jacqueline A; Glover, Edward; Pande, Kalyan et al. (2005) Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A 102:17858-63
Bunger, Maureen K; Walisser, Jacqueline A; Sullivan, Ruth et al. (2005) Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus. Genesis 41:122-32
Thomae, Tami L; Stevens, Emily A; Bradfield, Christopher A (2005) Transforming growth factor-beta3 restores fusion in palatal shelves exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem 280:12742-6
Walisser, Jacqueline A; Bunger, Maureen K; Glover, Edward et al. (2004) Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl Acad Sci U S A 101:16677-82
Lahvis, G P; Lindell, S L; Thomas, R S et al. (2000) Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice. Proc Natl Acad Sci U S A 97:10442-7

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