Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Project (R01)
Project #
7R01ES008421-02
Application #
2720950
Study Section
Special Emphasis Panel (ZRG4-ALTX-1 (01))
Project Start
1997-08-01
Project End
2001-07-31
Budget Start
1997-10-17
Budget End
1998-07-31
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
Winifred Masterson Burke Med Research Institute
Department
Type
DUNS #
780676131
City
White Plains
State
NY
Country
United States
Zip Code
10605
Pinto, John T; Krasnikov, Boris F; Alcutt, Steven et al. (2014) Kynurenine aminotransferase III and glutamine transaminase L are identical enzymes that have cysteine S-conjugate ?-lyase activity and can transaminate L-selenomethionine. J Biol Chem 289:30950-61
Jeitner, Thomas M; Cooper, Arthur J L (2014) Inhibition of human glutamine synthetase by L-methionine-S,R-sulfoximine-relevance to the treatment of neurological diseases. Metab Brain Dis 29:983-9
Vauzour, David; Pinto, John T; Cooper, Arthur J L et al. (2014) The neurotoxicity of 5-S-cysteinyldopamine is mediated by the early activation of ERK1/2 followed by the subsequent activation of ASK1/JNK1/2 pro-apoptotic signalling. Biochem J 463:41-52
Hallen, André; Jamie, Joanne F; Cooper, Arthur J L (2013) Lysine metabolism in mammalian brain: an update on the importance of recent discoveries. Amino Acids 45:1249-72
Tsikas, Dimitrios; Evans, Christopher E; Denton, Travis T et al. (2012) Stable isotope gas chromatography-tandem mass spectrometry determination of aminoethylcysteine ketimine decarboxylated dimer in biological samples. Anal Biochem 430:4-15
Halamkova, Lenka; Mailloux, Shay; Halamek, Jan et al. (2012) Enzymatic analysis of ýý-ketoglutaramate--a biomarker for hyperammonemia. Talanta 100:7-11
Cooper, Arthur J L; Krasnikov, Boris F; Pinto, John T et al. (2012) Comparative enzymology of (2S,4R)4-fluoroglutamine and (2S,4R)4-fluoroglutamate. Comp Biochem Physiol B Biochem Mol Biol 163:108-20
Bridges, Christy C; Krasnikov, Boris F; Joshee, Lucy et al. (2012) New insights into the metabolism of organomercury compounds: mercury-containing cysteine S-conjugates are substrates of human glutamine transaminase K and potent inactivators of cystathionine ?-lyase. Arch Biochem Biophys 517:20-9
Cooper, Arthur Jl; Pinto, John T; Callery, Patrick S (2011) Reversible and irreversible protein glutathionylation: biological and clinical aspects. Expert Opin Drug Metab Toxicol 7:891-910
Pinto, John T; Lee, Jeong-In; Sinha, Raghu et al. (2011) Chemopreventive mechanisms of ýý-keto acid metabolites of naturally occurring organoselenium compounds. Amino Acids 41:29-41

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