Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Research Project (R01)
Project #
5R01EY010243-03
Application #
2163976
Study Section
Visual Sciences A Study Section (VISA)
Project Start
1993-09-30
Project End
1996-12-31
Budget Start
1995-09-30
Budget End
1996-12-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Cedars-Sinai Medical Center
Department
Type
DUNS #
075307785
City
Los Angeles
State
CA
Country
United States
Zip Code
90048
Drolet, Barbra S; Mott, Kevin R; Lippa, Andrew M et al. (2004) Glycoprotein C of herpes simplex virus type 1 is required to cause keratitis at low infectious doses in intact rabbit corneas. Curr Eye Res 29:181-9
Perng, G C; Slanina, S M; Yukht, A et al. (2000) The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits. J Virol 74:1885-91
Drolet, B S; Perng, G C; Villosis, R J et al. (1999) Expression of the first 811 nucleotides of the herpes simplex virus type 1 latency-associated transcript (LAT) partially restores wild-type spontaneous reactivation to a LAT-null mutant. Virology 253:96-106
Perng, G C; Slanina, S M; Yukht, A et al. (1999) Herpes simplex virus type 1 serum neutralizing antibody titers increase during latency in rabbits latently infected with latency-associated transcript (LAT)-positive but not LAT-negative viruses. J Virol 73:9669-72
Perng, G C; Slanina, S M; Yukht, A et al. (1999) A herpes simplex virus type 1 latency-associated transcript mutant with increased virulence and reduced spontaneous reactivation. J Virol 73:920-9
Loutsch, J M; Perng, G C; Hill, J M et al. (1999) Identical 371-base-pair deletion mutations in the LAT genes of herpes simplex virus type 1 McKrae and 17syn+ result in different in vivo reactivation phenotypes. J Virol 73:767-71
Drolet, B S; Perng, G C; Cohen, J et al. (1998) The region of the herpes simplex virus type 1 LAT gene involved in spontaneous reactivation does not encode a functional protein. Virology 242:221-32
Perng, G C; Ghiasi, H; Slanina, S M et al. (1996) The spontaneous reactivation function of the herpes simplex virus type 1 LAT gene resides completely within the first 1.5 kilobases of the 8.3-kilobase primary transcript. J Virol 70:976-84
Perng, G C; Slanina, S M; Ghiasi, H et al. (1996) A 371-nucleotide region between the herpes simplex virus type 1 (HSV-1) LAT promoter and the 2-kilobase LAT is not essential for efficient spontaneous reactivation of latent HSV-1. J Virol 70:2014-8
Perng, G C; Ghiasi, H; Slanina, S M et al. (1996) High-dose ocular infection with a herpes simplex virus type 1 ICP34.5 deletion mutant produces no corneal disease or neurovirulence yet results in wild-type levels of spontaneous reactivation. J Virol 70:2883-93

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