The cellular, genetic, and biochemical bases of differences among inbred mice in the behaviors open field activity, defecation in the open field, cricket attacking, rope climbing, and alcohol preference are being investigated. A/J mice differ from C57-BL/6J mice in these behaviors. We are using A -- C57 chimeras to identify the cell populations which control the behaviors. Recombinant inbred (RI) strains derived from A and C57 parents are being used to enumerate and to map the genes controlling the behaviors. Biochemical and anatomical differences among the strains are being sought, and the relationship between such differences and behaviors will be studied in the RI strains. Our long term goal is to learn what genes control these behaviors, where the genes map, what their products are, in what cells they act, and what biochemical pathways they affect in affecting behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM029340-11S1
Application #
3276896
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1981-08-01
Project End
1989-06-30
Budget Start
1988-08-01
Budget End
1989-06-30
Support Year
11
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Type
Organized Research Units
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Lund, E; Nesbitt, M N (1988) The embryonic and adult mouse U1 snRNA genes map to different chromosomal loci. Somat Cell Mol Genet 14:143-8
Blatt, C; Saxe, D; Marzluff, W F et al. (1988) Mapping and gene order of U1 small nuclear RNA, endogenous viral env sequence, amylase, and alcohol dehydrogenase-3 on mouse chromosome 3. Somat Cell Mol Genet 14:133-42
LeClair, K P; Rabin, M; Nesbitt, M N et al. (1987) Murine Ly-6 multigene family is located on chromosome 15. Proc Natl Acad Sci U S A 84:1638-42