This proposal deseribes a program directed towards the total synthesis of aurodox (1) and application of the methodology to be developed to the synthesis of other natural and unnatural members of the elfamycin family. The proposed methodology includes (a) a stereocontrolled approach from carbohydrate precursors and (b) an asymmetric approach from achiral precursors designed also with high stereo control as a prime objective. Since aurodox (1) and its relatives exhibit potent antibiotic properties by inhibiting protein biosynthesis as well as ionophoric and growth-promoting activites, this program should contribute significantly to human and animal medicine as well as result in useful biological tools and new synthetic methodology.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032192-05
Application #
3280813
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1983-09-15
Project End
1991-12-31
Budget Start
1988-01-01
Budget End
1988-12-31
Support Year
5
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Arts and Sciences
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104