This program is directed towards the completion of the total synthesis of brevetoxin A and ciguatoxin. Both compounds are potent neurotoxins isolated from marine organisms. Their total syntheses are expected to be accompanied by discoveries in the area of mew synthetic technologies and strategies and may have implications in the neurosciences, the understanding and protection of the marine environment, and medicine. The key steps in the syntheses involve the application of novel methods for the construction of 6-, 7-, 8- and 9-membered cyclic ethers using thionoesters, thionolactones, hydroxyepoxides, hydroxyketones and hydroxydithioketals as precursors.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM032192-12
Application #
2176473
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1989-09-01
Project End
1994-12-31
Budget Start
1994-01-01
Budget End
1994-12-31
Support Year
12
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037