New radical and radical chain reactions will be invented of value in the partial or total synthesis of biologically active Natural Products. New reactions for amination and fluorination are proposed. The design of reactions for the labelling of leucotrienes, prostaglandins and many peptides is foreseen. The synthesis of a number of (at present) difficulty available, but important, peptides using the new radical chemistry of the easily available thiohydroxamic esters is planned. A new ether synthesis will be invented which could facilitate the formation of the glycosidic linkage. A new method of generation of radicals in pairs for phenolate coupling is proposed. An accumulator of radicals to permit efficient radical pairing is also envisaged. Radical modification of nucleosides and nucleotides in the aromatic parts of the molecule is proposed.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
5R01GM037943-04
Application #
3293815
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1987-04-01
Project End
1992-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Texas A&M University
Department
Type
Schools of Arts and Sciences
DUNS #
City
College Station
State
TX
Country
United States
Zip Code
77845