Radical and radical chain reactions will be invented of value in the partial or total synthesis of biologically active natural products with especial emphasis on the manipulation of nucleosides. In view of the ever more important applications of radical deoxygenation of alcohols in nucleoside to 2-deoxynucleoside synthesis, new and non-toxic reagents will be developed. New methods of radical synthesis of isosteric phosphonates at the 3'-position in nucleosides are planned. 3', 5'-Phosphonates with both the 5'- and the 3'-oxygen replaced by CH2 should be of biological interest. Improved methods for the conversion of 1,2-dixanthates to olefins are planned. A new reaction for the conversion of an alcohol stereospecifically to an oxygenated alkyl or alkenyl group is programmed for invention.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
2R01GM037943-06
Application #
3293812
Study Section
Medicinal Chemistry Study Section (MCHA)
Project Start
1987-04-01
Project End
1996-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Texas A&M University
Department
Type
Schools of Earth Sciences/Natur
DUNS #
City
College Station
State
TX
Country
United States
Zip Code
77845