Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Project (R01)
Project #
3R01GM059790-04S1
Application #
6794238
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Wolfe, Paul B
Project Start
2000-05-01
Project End
2007-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
4
Fiscal Year
2003
Total Cost
$17,000
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
Organized Research Units
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Dedon, Peter C (2008) The chemical toxicology of 2-deoxyribose oxidation in DNA. Chem Res Toxicol 21:206-19
Jiang, Tao; Zhou, Xinfeng; Taghizadeh, Koli et al. (2007) N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage. Proc Natl Acad Sci U S A 104:60-5
Pang, Bo; Zhou, Xinfeng; Yu, Hongbin et al. (2007) Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation. Carcinogenesis 28:1807-13
Chen, Bingzi; Vu, Choua C; Byrns, Michael C et al. (2006) Formation of 1,4-dioxo-2-butene-derived adducts of 2'-deoxyadenosine and 2'-deoxycytidine in oxidized DNA. Chem Res Toxicol 19:982-5
Zhou, Xinfeng; Liberman, Rosa G; Skipper, Paul L et al. (2005) Quantification of DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry: application to gamma-radiation and peroxynitrite. Anal Biochem 343:84-92
Collins, Christiane; Zhou, Xinfeng; Wang, Rong et al. (2005) Differential oxidation of deoxyribose in DNA by gamma and alpha-particle radiation. Radiat Res 163:654-62
Zhou, Xinfeng; Taghizadeh, Koli; Dedon, Peter C (2005) Chemical and biological evidence for base propenals as the major source of the endogenous M1dG adduct in cellular DNA. J Biol Chem 280:25377-82
Bohnert, Tonika; Gingipalli, Lakshmaiah; Dedon, Peter C (2004) Reaction of 2'-deoxyribonucleosides with cis- and trans-1,4-dioxo-2-butene. Biochem Biophys Res Commun 323:838-44
Collins, Christiane; Awada, Mohamad M; Zhou, Xinfeng et al. (2003) Analysis of 3'-phosphoglycolaldehyde residues in oxidized DNA by gas chromatography/negative chemical ionization/mass spectrometry. Chem Res Toxicol 16:1560-6
Plastaras, John P; Dedon, Peter C; Marnett, Lawrence J (2002) Effects of DNA structure on oxopropenylation by the endogenous mutagens malondialdehyde and base propenal. Biochemistry 41:5033-42

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