Birth complications have medical and neurobehavioral consequences. In the United States, birth complications of unknown origin continue to account for at least 50% of the reported cases. The proposed project is designed to examine the contribution of maternal stress to adverse birth outcomes. In addition, neuroendocrine response (beta-endorphins, ACTH, cortisol, CRF, and catecholamines) and measures of fetal physiology will be assessed as possible markers of stress and predictors of outcome. Over a three year period, 375 women, half Hispanic, and half Anglo, selected from a total population of over 7,200 will be assessed during the third trimester of their pregnancy with measures of stress and strain (response to stress). In addition, maternal plasma will be collected for assays of beta-endorphins, ACTH, CRF and cortisol, and maternal urine for catecholamines. These peptides have been selected because they are responsive to stress, and have effects on the course of pregnancy and birth outcome. Measures of fetal physiology, including doppler velocimetry of the uteroplacental circulation and fetal heart rate under resting and challenge conditions will be taken. At birth, maternal and cord (infant) blood will be collected and analyzed for levels of neuropeptides. Birth and delivery outcomes will be determined. Multivariate models to predict the effects of stress and strain on birth complications will be constructed.
| Stout, Stephanie A; Espel, Emma V; Sandman, Curt A et al. (2015) Fetal programming of children's obesity risk. Psychoneuroendocrinology 53:29-39 |
| Sandman, Curt A; Buss, Claudia; Head, Kevin et al. (2015) Fetal exposure to maternal depressive symptoms is associated with cortical thickness in late childhood. Biol Psychiatry 77:324-34 |
| Sandman, Curt A (2015) Fetal exposure to placental corticotropin-releasing hormone (pCRH) programs developmental trajectories. Peptides 72:145-53 |
| Hilmert, Clayton J; Dominguez, Tyan Parker; Schetter, Christine Dunkel et al. (2014) Lifetime racism and blood pressure changes during pregnancy: implications for fetal growth. Health Psychol 33:43-51 |
| Sandman, Curt A; Head, Kevin; Muftuler, L Tugan et al. (2014) Shape of the basal ganglia in preadolescent children is associated with cognitive performance. Neuroimage 99:93-102 |
| Sandman, Curt A; Glynn, Laura M; Davis, Elysia Poggi (2013) Is there a viability-vulnerability tradeoff? Sex differences in fetal programming. J Psychosom Res 75:327-35 |
| Hahn-Holbrook, Jennifer; Schetter, Christine Dunkel; Arora, Chander et al. (2013) Placental Corticotropin-Releasing Hormone Mediates the Association Between Prenatal Social Support and Postpartum Depression. Clin Psychol Sci 1:253-264 |
| Sandman, Curt A; Davis, Elysia P; Buss, Claudia et al. (2012) Exposure to prenatal psychobiological stress exerts programming influences on the mother and her fetus. Neuroendocrinology 95:7-21 |
| Sandman, Curt A; Davis, Elysia Poggi; Glynn, Laura M (2012) Prescient human fetuses thrive. Psychol Sci 23:93-100 |
| Davis, Elysia Poggi; Sandman, Curt A (2012) Prenatal psychobiological predictors of anxiety risk in preadolescent children. Psychoneuroendocrinology 37:1224-33 |
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