A continuing longitudinal study is planned to measure blood pressure, height, weight and skinfold thickness of 1223 children (476 black, 747 white), twice annually, for 5 years and to continue to measure Type A behavior in 618 children annually. The study sample is a stable population of children selected from more than 98% of 10,500 children being all children in grades 1, 2, and 3 of the Minneapolis Public School System in the Spring of 1978. All children from the top and bottom 5% of the systolic blood pressure (BP) distribution and a 1/2 sample of black children and a 1/9 sample of white children from the rest of the BP distribution were followed 2x per year in spring and fall of 1978, 1979, and 1980 for BP and body size measurements. These 1200+ children have also been visited at home and extensive psychological, medical history, dietary history, demographic data, and overnight urine collections for Na+, K+ and creatinine have been gathered. In addition blood pressure, height, weight, medical history, psychological data and Life Event data have been gathered on the parents. In 1981 no screening was performed but consent was obtained to continue screening throughout the remaining years of school. In 1982, 22+ Na red blood cell (rbc) efflux rate was measured in 395 children and 602 parents. In addition, Type A behavior patterns were measured in 618 children and their parents. During the course of the study baseline data and laboratory and Type A classification data will be used to develop predictive equations for blood pressure levels in the highest percentiles in late adolescence. This will include derivation of an index of """"""""tracking"""""""" and the predictive value of this index. These may provide etiological clues to essential hypertension and allow in depth study of other factors among children to be found at highest risk. From such proposed predictive studies it will be possible to develop strategies for primary prevention and more intricate examination of etiological factors. During the first phase of this study 1978-80 subsamples of children were examined to determine psychological antecedents of Type A behavior in adults and differences in the sympathetic nervous system and renin-angiotension system between children with relatively high and low blood pressure. The Type A studies will be expanded in the present study.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL019877-09
Application #
3335989
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1977-09-01
Project End
1986-05-31
Budget Start
1985-06-01
Budget End
1986-05-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Public Health
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Lee, Jong Y; Prineas, Ronald J; Eaton, John W (2009) Heritability of erythrocyte sodium permeability: a possible genetic marker for hypertension. Ann Clin Lab Sci 39:241-50
Sinaiko, A R; Donahue, R P; Jacobs Jr, D R et al. (1999) Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children's Blood Pressure Study. Circulation 99:1471-6
Munger, R G; Booton, E A (1998) Bangungut in Manila: sudden and unexplained death in sleep of adult Filipinos. Int J Epidemiol 27:677-84
Lee, D J; Gomez-Marin, O; Prineas, R J (1996) Type A behavior pattern and change in blood pressure from childhood to adolescence. The Minneapolis Children's Blood Pressure Study. Am J Epidemiol 143:63-72
Donahue, R P; Prineas, R J; Gomez, O et al. (1994) Tracking of elevated systolic blood pressure among lean and overweight adolescents: the Minneapolis Children's Blood Pressure Study. J Hypertens 12:303-8
Rautaharju, P M; Zhou, S H; Wong, S et al. (1993) Functional characteristics of QT prediction formulas. The concepts of QTmax and QT rate sensitivity. Comput Biomed Res 26:188-204
Gomez-Marin, O; Prineas, R J; Rastam, L (1992) Cuff bladder width and blood pressure measurement in children and adolescents. J Hypertens 10:1235-41
Rautaharju, P M; Zhou, S H; Wong, S et al. (1992) Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol 8:690-5
Donahue, R P; Prineas, R J; Gomez, O et al. (1992) Familial resemblance of body fat distribution: the Minneapolis Children's Blood Pressure Study. Int J Obes Relat Metab Disord 16:161-7
Munger, R G; Gomez-Marin, O; Prineas, R J et al. (1991) Elevated blood pressure among Southeast Asian refugee children in Minnesota. Am J Epidemiol 133:1257-65

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