Individual differences in blood pressure (BP) change and BP elevation may be due in part to differences in the mechanisms regulating BP and BP reactivity. This project has two related components; 1) to continue longitudinal assessments of BP, body weight, height body fat distribution, etc, in a cohort of 817 subjects who have been examined semi-annually since 1978; and 2) to compare a """"""""high risk"""""""" group of subjects (top quintile of systolic BP on three consecutive occasions) to a randomly selected comparison group to explore the relationships between plasma insulin and (BP) and BP reactivity as a function of obesity, fat distribution, catecholamine concentrations, and sodium flux. The proposed study will reexamine 817 healthy men and women aged 18-21 years who have participated in the Minneapolis Children's BP Study since 1978. We will assess the longitudinal predictors of BP change from childhood to young adulthood. The effects of somatic growth, body fat distribution, parental BP and obesity, and several health habits and behaviors on BP change will be estimated from repeated measures taken over the last 12 years. The second component of this study will evaluate the association between insulin and BP and BP reactivity in a group of subjects at risk for essential hypertension and a comparison group. We will quantitate glucose and insulin (fasting and after a glucose load), serum concentrations of epinephrine and norepinephrine, and sodium transport across the red blood cell membrane to better study their complex interrelationships with BP. Differences in obesity, fat distribution, physical activity and other covariates will be taken into account in the analyses. This study should provide valuable insight into mechanisms through which physiologic and biobehavioral factors interact to effect blood pressure regulation.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL019877-16
Application #
3335993
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1989-06-01
Project End
1996-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
16
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Miami School of Medicine
Department
Type
Schools of Medicine
DUNS #
City
Miami
State
FL
Country
United States
Zip Code
33146
Lee, Jong Y; Prineas, Ronald J; Eaton, John W (2009) Heritability of erythrocyte sodium permeability: a possible genetic marker for hypertension. Ann Clin Lab Sci 39:241-50
Sinaiko, A R; Donahue, R P; Jacobs Jr, D R et al. (1999) Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children's Blood Pressure Study. Circulation 99:1471-6
Munger, R G; Booton, E A (1998) Bangungut in Manila: sudden and unexplained death in sleep of adult Filipinos. Int J Epidemiol 27:677-84
Lee, D J; Gomez-Marin, O; Prineas, R J (1996) Type A behavior pattern and change in blood pressure from childhood to adolescence. The Minneapolis Children's Blood Pressure Study. Am J Epidemiol 143:63-72
Donahue, R P; Prineas, R J; Gomez, O et al. (1994) Tracking of elevated systolic blood pressure among lean and overweight adolescents: the Minneapolis Children's Blood Pressure Study. J Hypertens 12:303-8
Rautaharju, P M; Zhou, S H; Wong, S et al. (1993) Functional characteristics of QT prediction formulas. The concepts of QTmax and QT rate sensitivity. Comput Biomed Res 26:188-204
Gomez-Marin, O; Prineas, R J; Rastam, L (1992) Cuff bladder width and blood pressure measurement in children and adolescents. J Hypertens 10:1235-41
Rautaharju, P M; Zhou, S H; Wong, S et al. (1992) Sex differences in the evolution of the electrocardiographic QT interval with age. Can J Cardiol 8:690-5
Donahue, R P; Prineas, R J; Gomez, O et al. (1992) Familial resemblance of body fat distribution: the Minneapolis Children's Blood Pressure Study. Int J Obes Relat Metab Disord 16:161-7
Munger, R G; Gomez-Marin, O; Prineas, R J et al. (1991) Elevated blood pressure among Southeast Asian refugee children in Minnesota. Am J Epidemiol 133:1257-65

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