Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL027317-04
Application #
3339076
Study Section
(SSS)
Project Start
1982-09-30
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
4
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Sastry, S S; Kun, E (1990) The interaction of adenosine diphosphoribosyl transferase (ADPRT) with a cruciform DNA. Biochem Biophys Res Commun 167:842-7
Sastry, S S; Buki, K G; Kun, E (1989) Binding of adenosine diphosphoribosyltransferase to the termini and internal regions of linear DNAs. Biochemistry 28:5670-80
Sooki-Toth, A; Banfalvi, G; Szollosi, J et al. (1989) Cellular regulation of ADP-ribosylation of proteins. III. Selective augmentation of in vitro ADP-ribosylation of histone H3 in murine thymic cells after in vivo emetine treatment. Exp Cell Res 184:44-52
Buki, K G; Kun, E (1988) Polypeptide domains of ADP-ribosyltransferase obtained by digestion with plasmin. Biochemistry 27:5990-5
Kun, E (1988) Probable macromolecular mechanisms of gene regulation by adenosine diphosphoribosyl transferase (ADPRT). Adv Exp Med Biol 231:613-26
Sastry, S S; Kun, E (1988) Molecular interactions between DNA, poly(ADP-ribose) polymerase, and histones. J Biol Chem 263:1505-12
Tseng Jr, A; Lee, W M; Jakobovits, E B et al. (1987) Prevention of tumorigenesis of oncogene-transformed rat fibroblasts with DNA site inhibitors of poly(ADP ribose) polymerase. Proc Natl Acad Sci U S A 84:1107-11
McLick, J; Hakam, A; Bauer, P I et al. (1987) Benzamide-DNA interactions: deductions from binding, enzyme kinetics and from X-ray structural analysis of a 9-ethyladenine-benzamide adduct. Biochim Biophys Acta 909:71-83
Hakam, A; McLick, J; Buki, K et al. (1987) Catalytic activities of synthetic octadeoxyribonucleotides as coenzymes of poly(ADP-ribose) polymerase and the identification of a new enzyme inhibitory site. FEBS Lett 212:73-8
McLick, J; Bauer, P I; Hakam, A et al. (1987) Covalent binding of 4-carbamoylbenzenediazonium chloride to deoxyguanine bases of DNA resulting in apparent irreversible inhibition of poly(adenosine diphosphoribose) polymerase at the nicotinamide binding site. Biochemistry 26:2226-31

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