This is a proposal to use the National Death Index to determine the 10 year mortality status of the 361,662 middle-aged men screened in 1973-75 for the Multiple Risk Factor Intervention Trial, to complete a number of analyses on the relationship of diastolic blood pressure, serum cholesterol and cigarette smoking with death from cardiovascular disease and cancer, and to initiate new analyses on the seasonal variation of cardiovascular risk factors and endpoints. Over 17,000 deaths have been identified in this cohort to date using data from the Social Security Administration; death certificates have been collected and coded for approximately 14,000 of these deaths. We estimate that using only the SSA for vital status ascertainment, we will miss 25% of the deaths occurring in calender years 1982-85, a period of follow-up in which the mortality has increased due to aging of the cohort. Over the entire period of follow-up in which the mortality has increased due to aging of the cohort. Over the entire period of follow-up from 1974 the death ascertainment rate is estimated to be 80% if SSA is used. Our analyses with the 12,866 MRFIT randomized participants indicate that a 98% ascertainment rate would be achieved using the National Death Index for this critical time period, and the overall death ascertainment rate from 1974 to 1985 would be increased to 95%. With the complete 10 year follow-up of this large group of men analyses on risk factors from stroke and site specific cancer will be completed. In addition, this data set will be used to study the risks associated with isolated systolic hypertension, the seasonal and geographic variation in levels of serum cholesterol and blood pressure and the cyclic nature of cardiovascular disease. Using data from the Census Bureau (education and income levels by zip code), the socio-economic status of participants will be indirectly estimated and the coronary heart disease and cancer death rate difference between white and black men will be evaluated by social class. This data set on risk factors and mortality outcome is unique with respect to size and to the high level of quality control imposed during data collection. These aspects make the data particularly valuable for long-term follow-up and analysis.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL028715-08
Application #
3340024
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1982-04-01
Project End
1990-07-31
Budget Start
1989-08-01
Budget End
1990-07-31
Support Year
8
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Public Health
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Stamler, J; Stamler, R; Neaton, J D et al. (1999) Low risk-factor profile and long-term cardiovascular and noncardiovascular mortality and life expectancy: findings for 5 large cohorts of young adult and middle-aged men and women. JAMA 282:2012-8
Vaccaro, O; Stamler, J; Neaton, J D (1998) Sixteen-year coronary mortality in black and white men with diabetes screened for the Multiple Risk Factor Intervention Trial (MRFIT). Int J Epidemiol 27:636-41
Davey Smith, G; Neaton, J D; Wentworth, D et al. (1998) Mortality differences between black and white men in the USA: contribution of income and other risk factors among men screened for the MRFIT. MRFIT Research Group. Multiple Risk Factor Intervention Trial. Lancet 351:934-9
Neaton, J D; Wentworth, D N (1997) Low serum cholesterol and risk of death from AIDS. AIDS 11:929-30
Brancati, F L; Whelton, P K; Randall, B L et al. (1997) Risk of end-stage renal disease in diabetes mellitus: a prospective cohort study of men screened for MRFIT. Multiple Risk Factor Intervention Trial. JAMA 278:2069-74
Klag, M J; Whelton, P K; Randall, B L et al. (1997) End-stage renal disease in African-American and white men. 16-year MRFIT findings. JAMA 277:1293-8
Coughlin, S S; Neaton, J D; Randall, B et al. (1997) Predictors of mortality from kidney cancer in 332,547 men screened for the Multiple Risk Factor Intervention Trial. Cancer 79:2171-7
Smith, G D; Wentworth, D; Neaton, J D et al. (1996) Socioeconomic differentials in mortality risk among men screened for the Multiple Risk Factor Intervention Trial: II. Black men. Am J Public Health 86:497-504
Smith, G D; Neaton, J D; Wentworth, D et al. (1996) Socioeconomic differentials in mortality risk among men screened for the Multiple Risk Factor Intervention Trial: I. White men. Am J Public Health 86:486-96
Coughlin, S S; Neaton, J D; Sengupta, A (1996) Cigarette smoking as a predictor of death from prostate cancer in 348,874 men screened for the Multiple Risk Factor Intervention Trial. Am J Epidemiol 143:1002-6

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