Abstract

This is a proposal to use the National Death Index to determine 16 year mortality status of the 361,662 middle-aged men screened in 1973-75 for the Multiple Risk Factor Intervention Trial. These data will be used to study the persistence of associations of blood pressure, serum cholesterol and cigarette smoking with coronary, stroke and cancer mortality, to compare risk association with all cause and cause-specific mortality among Hispanics, white non-hispanics and blacks and to assess risk factor relationship with rare cancers and with conditions frequently mentioned on the death certificate but rarely specified as the underlying cause of death. Over 24,00 deaths have been identified in this cohort to date using the National Death Index through 12 years of follow-up. Death certificates have been collected and coded by nosologists for 23,778 (99%). Among these 23,778 deaths, 8,168 deaths are due to coronary heart disease; 788 deaths are due to stroke; 8,061 deaths are due to cancer; 844 deaths are due to digestive diseases; and 794 deaths are due to respiratory diseases. Among the cancers, we have recorded 2,657 due to lung, 1,043 due to a 10% increase in the number of deaths per year, that the four additional calendar years of follow-up proposed will bring the total number of decedents to over 40,000 approximately 11% of the total number of men screened. With such a large number of deaths, analyses of uncommon causes of death can be studied and their association with cholesterol, blood pressure, cigarette smoking, and race analyzed and documented. Recently acquired meteorological and demographic data for small areas will be used to search for possible relationship of such factors to variables into risk factor analyses. This data set on risk factors and mortality outcome is unparalleled with respect to size and to the high level of quality control imposed during data collection. These aspects make these data particularly valuable for long-term follow-up and analyses.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL028715-11
Application #
3340026
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1982-04-01
Project End
1995-07-31
Budget Start
1992-08-01
Budget End
1993-07-31
Support Year
11
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
Schools of Public Health
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Stamler, J; Stamler, R; Neaton, J D et al. (1999) Low risk-factor profile and long-term cardiovascular and noncardiovascular mortality and life expectancy: findings for 5 large cohorts of young adult and middle-aged men and women. JAMA 282:2012-8
Vaccaro, O; Stamler, J; Neaton, J D (1998) Sixteen-year coronary mortality in black and white men with diabetes screened for the Multiple Risk Factor Intervention Trial (MRFIT). Int J Epidemiol 27:636-41
Davey Smith, G; Neaton, J D; Wentworth, D et al. (1998) Mortality differences between black and white men in the USA: contribution of income and other risk factors among men screened for the MRFIT. MRFIT Research Group. Multiple Risk Factor Intervention Trial. Lancet 351:934-9
Neaton, J D; Wentworth, D N (1997) Low serum cholesterol and risk of death from AIDS. AIDS 11:929-30
Brancati, F L; Whelton, P K; Randall, B L et al. (1997) Risk of end-stage renal disease in diabetes mellitus: a prospective cohort study of men screened for MRFIT. Multiple Risk Factor Intervention Trial. JAMA 278:2069-74
Klag, M J; Whelton, P K; Randall, B L et al. (1997) End-stage renal disease in African-American and white men. 16-year MRFIT findings. JAMA 277:1293-8
Coughlin, S S; Neaton, J D; Randall, B et al. (1997) Predictors of mortality from kidney cancer in 332,547 men screened for the Multiple Risk Factor Intervention Trial. Cancer 79:2171-7
Smith, G D; Wentworth, D; Neaton, J D et al. (1996) Socioeconomic differentials in mortality risk among men screened for the Multiple Risk Factor Intervention Trial: II. Black men. Am J Public Health 86:497-504
Smith, G D; Neaton, J D; Wentworth, D et al. (1996) Socioeconomic differentials in mortality risk among men screened for the Multiple Risk Factor Intervention Trial: I. White men. Am J Public Health 86:486-96
Coughlin, S S; Neaton, J D; Sengupta, A (1996) Cigarette smoking as a predictor of death from prostate cancer in 348,874 men screened for the Multiple Risk Factor Intervention Trial. Am J Epidemiol 143:1002-6

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