Abstract

After four years of grant support, we have enrolled three cohorts of twin families consisting of 11 year old twins and their mother and father. To date we have had 336 family visits to the study. The attrition rate from the first visit to the second visit has been 3.7%. The overall goals of this design are to analyze the genetic and environmental contributions of juvenile hemodynamic determinants of blood pressure to adult cardiovascular (CV) risk. These goals will be achieved by a laboratory study of hemodynamic measures in a longitudinal study of 1,200 juvenile twins age 9.5 to 17 years and their parents. The specific hypotheses represent a progressive approach to hypothesis testing beginning with 1) an epidemiologic analysis which does not exploit familial resemblance; 2) a more refined univariate analysis of genetic and environmental effects exploiting the unique aspects of the twin-parent design; 3) an analysis of the developmental change in the genetic and environmental effects using the power of longitudinal designing; and 4) a multivariate developmental analysis of the interrelationships among the cardiovascular variables. The analysis will address the following general questions: 1) What are the relationships between hemodynamic variables and family history of CV disease to the level of blood pressure in children. 2) What are the contributions of genes and environment to family resemblance. 3) Do genetic and environmental effects upon blood pressure change during development. 4) How do genes and environment contribute to the interrelationships between blood pressure and its hemodynamic determinants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL031010-08
Application #
3342021
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1983-08-01
Project End
1993-07-31
Budget Start
1990-08-01
Budget End
1991-07-31
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Moskowitz, W B; Schwartz, P F; Schieken, R M (1999) Childhood passive smoking, race, and coronary artery disease risk: the MCV Twin Study. Medical College of Virginia. Arch Pediatr Adolesc Med 153:446-53
Nance, W E; Bodurtha, J; Eaves, L J et al. (1998) Models for the longitudinal genetic analysis of same-age twins: application to HDL cholesterol. Twin Res 1:3-8
van den Bree, M B; Schieken, R M; Moskowitz, W B et al. (1996) Genetic regulation of hemodynamic variables during dynamic exercise. The MCV twin study. Circulation 94:1864-9
Verhaaren, H A; Schieken, R M; Schwartz, P et al. (1994) Cardiovascular reactivity in isometric exercise and mental arithmetic in children. J Appl Physiol 76:146-50
Newkumet, K M; Goble, M M; Young, R B et al. (1994) Altered blood pressure reactivity in adolescent diabetics. Pediatrics 93:616-21
Austin, M J; Neale, M C; Corey, L A et al. (1993) Common fragile site expression in lymphocytes from an individual mosaic for trisomy 8. Am J Med Genet 45:570-1
Schieken, R M (1993) Genetic factors that predispose the child to develop hypertension. Pediatr Clin North Am 40:1-11
Schieken, R (1993) Premature atherosclerosis and familial hypercholesterolemia. Coron Artery Dis 4:126-32
Moore, W E; Burmeister, J A; Brooks, C N et al. (1993) Investigation of the influences of puberty, genetics, and environment on the composition of subgingival periodontal floras. Infect Immun 61:2891-8
Schieken, R M; Mosteller, M; Goble, M M et al. (1992) Multivariate genetic analysis of blood pressure and body size. The Medical College of Virginia Twin Study. Circulation 86:1780-8

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