Abstract

The purpose of this study is to assess the value of the laser in removal of arteriosclerotic plaque from blood vessels. The proposed research would evaluate the currently available lasers for wavelength, energy, and power that are efficacious in the removal of plaque in human cadaver vessels and damaged rabbit vessels. The latter method would involve inducing plaque formation followed by laser removal and subsequent short and long term followup employing histopathological examination. It is the primary goal of this proposal to determine if this method of approaching the control of arteriosclerosis is feasible, and has minimal negative effects. The final year of study would involve human trials only if the results of the initial two years were positive. The unique equipment of the NIH Laser Biotechnology Resource (LAMP) would be used in this study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL031318-03
Application #
3342418
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1983-12-01
Project End
1986-11-30
Budget Start
1985-12-01
Budget End
1986-11-30
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Baribeau, Y; Eugene, J; Nhu, T T et al. (1991) Excimer laser radiation for endarterectomy of experimental atheromas. J Invest Surg 4:247-58
Eugene, J; Ott, R A; Nudelman, K L et al. (1990) Initial clinical evaluation of carotid artery laser endarterectomy. J Vasc Surg 12:499-503
Eugene, J; Ott, R A; Baribeau, Y et al. (1990) Initial trial of argon ion laser endarterectomy for peripheral vascular disease. Arch Surg 125:1007-10;discussion 1010-1
Baribeau, Y; Eugene, J; Firestein, S L et al. (1990) Comparison of contact and free beam laser endarterectomy. J Surg Res 48:127-33
Berns, M W; Wright, W H; Tromberg, B J et al. (1989) Use of a laser-induced optical force trap to study chromosome movement on the mitotic spindle. Proc Natl Acad Sci U S A 86:4539-43
Tobis, J; Smolin, M; Mallery, J et al. (1989) Laser-assisted thermal angioplasty in human peripheral artery occlusions: mechanism of recanalization. J Am Coll Cardiol 13:1547-54
Rasmussen, R E; Hammer-Wilson, M; Berns, M W (1989) Mutation and sister chromatid exchange induction in Chinese hamster ovary (CHO) cells by pulsed excimer laser radiation at 193 nm and 308 nm and continuous UV radiation at 254 nm. Photochem Photobiol 49:413-8
Morcos, N C; Berns, M; Henry, W L (1988) Effect of laser-heated tip angioplasty on human atherosclerotic coronary arteries. Lasers Surg Med 8:22-9
Morcos, N C; Berns, M; Henry, W L (1988) Phycocyanin: laser activation, cytotoxic effects, and uptake in human atherosclerotic plaque. Lasers Surg Med 8:10-7
Pollock, M E; Eugene, J; Hammer-Wilson, M et al. (1987) Photosensitization of experimental atheromas by porphyrins. J Am Coll Cardiol 9:639-46

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