Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL044006-05S1
Application #
2221251
Study Section
Metabolism Study Section (MET)
Project Start
1990-01-01
Project End
1996-12-31
Budget Start
1994-01-01
Budget End
1996-12-31
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Rosalind Franklin University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
069501252
City
North Chicago
State
IL
Country
United States
Zip Code
60064

  Publications

Peffley, D M; Gayen, A K; Morand, O H (1998) Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071): Biochem Pharmacol 56:439-49
Peffley, D M; Gayen, A K (1997) Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level. Arch Biochem Biophys 337:251-60
Gayen, A K; Peffley, D M (1995) The length of 5'-untranslated leader sequences influences distribution of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in polysomes: effects of lovastatin, oxysterols, and mevalonate. Arch Biochem Biophys 322:475-85
Peffley, D M; Gayen, A K (1995) Mevalonate regulates polysome distribution and blocks translation-dependent suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA: relationship to translational control. Somat Cell Mol Genet 21:189-204
Choi, J W; Peffley, D M (1995) 3'-untranslated sequences mediate post-transcriptional regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA by 25-hydroxycholesterol. Biochem J 307 ( Pt 1):233-8
Choi, J W; Lundquist, E N; Peffley, D M (1993) Inhibition of protein synthesis in baby-hamster kidney cells blocks oxysterol-mediated suppression of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA at a post-transcriptional level. Biochem J 296 ( Pt 3):859-66
Peffley, D M (1992) Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis in Syrian hamster C100 cells by mevinolin, 25-hydroxycholesterol, and mevalonate: the role of posttranscriptional control. Somat Cell Mol Genet 18:19-32