The four specific aims are to [1] elucidate the cellular biology of Ts1 and LRP by identifying structural domains of Ts1 that define LRP recognition, [2] define the structural determinants of Ts1 which allow RAP to regulate by LRP, [3] elucidate the mechanisms by which RAP regulates activity of LRP within the cell, and [4] define routes of intercellular trafficking of both LRP and RAP. These studies will have broad implications for understanding the normal and pathophysiological alterations which occur in developing vasculature.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052040-07
Application #
6183446
Study Section
Pathology A Study Section (PTHA)
Project Start
1997-04-15
Project End
2002-03-31
Budget Start
2000-04-01
Budget End
2002-03-31
Support Year
7
Fiscal Year
2000
Total Cost
$283,869
Indirect Cost
Name
Washington University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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