We propose to develop a novel computer architecture that will support automated reasoning about protocol-based care. We will build on our previous experience in developing the ONCOCIN and T-HELPER systems to create a highly integrated set of computer programs that will significantly ease the construction of new automated systems that can use knowledge of clinical protocols and guidelines to interpret electronically stored patient data and to monitor patient management. Our approach will allow a wide range of clinical information systems to determine when clinical practice guidelines and protocols may apply to given patients, to recommend therapy in accordance with those guidelines, and to critique patient care that deviates from recommended practice patterns. The goal of our research is to address fundamental deficiencies in existing automated approaches to guideline-directed therapy by developing both new data models that can capture the necessary temporal distinctions in patient data and new problem-solving methods for reasoning about guideline- directed therapy. Our research plan consists of a four-step process that defines our specific aims. (1) We will create a domain model of medical concepts that is sufficient to represent the elements of clinical medicine required for a subset of protocol-based care in three areas of medicine: oncology, HIV infection, and hypertension. (2) We will create a temporal data management system that will derive automatically time-related abstractions from primary clinical data. This system will support a new database query language that will allow software clients to query for the presence of time-related abstractions in clinical data, in addition to the primary data themselves. (3) We will develop several extensible problem-solving methods for protocol-based care that will be reusable within the three clinical domains that we will explore. These methods will automate the tasks of therapy planning, of determining patient eligibility for protocols and guidelines, and of critiquing provider's management of patients when practice guidelines apply. (4) We will evaluate the applicability of our problem-solving architecture to different classes of clinical protocols. We will reintegrate our architecture into the T-HELPER medical workstation, and will test the architecture's ability to support reasoning about guidelines and protocols in the three clinical application areas that we will explore. At the conclusion of our work, we will have developed a validated software architecture that can support temporal-data management and automated reasoning about complex clinical protocols and guidelines. Because of our commitment to industry standards such as UNIX, C, TCP/IP, and SQL, our system will be usable as an open """"""""server"""""""" for temporal-data management within a variety of application programs.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Research Project (R01)
Project #
1R01LM005708-01
Application #
2238080
Study Section
Special Emphasis Panel (SRC)
Project Start
1995-04-01
Project End
1998-03-31
Budget Start
1995-04-01
Budget End
1996-03-31
Support Year
1
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Stanford University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
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Martins, S B; Lai, S; Tu, S et al. (2006) Offline testing of the ATHENA Hypertension decision support system knowledge base to improve the accuracy of recommendations. AMIA Annu Symp Proc :539-43
Goldstein, Mary K; Coleman, Robert W; Tu, Samson W et al. (2004) Translating research into practice: organizational issues in implementing automated decision support for hypertension in three medical centers. J Am Med Inform Assoc 11:368-76
Peleg, Mor; Tu, Samson; Manindroo, Abhijit et al. (2004) Modeling and analyzing biomedical processes using workflow/Petri Net models and tools. Medinfo 11:74-8
Advani, Aneel; Jones, Neil; Shahar, Yuval et al. (2004) An intelligent case-adjustment algorithm for the automated design of population-based quality auditing protocols. Medinfo 11:1003-7
Advani, Aneel; Goldstein, Mary; Shahar, Yuval et al. (2003) Developing quality indicators and auditing protocols from formal guideline models: knowledge representation and transformations. AMIA Annu Symp Proc :11-5
Tu, Samson W; Campbell, James; Musen, Mark A (2003) The structure of guideline recommendations: a synthesis. AMIA Annu Symp Proc :679-83
Peleg, Mor; Tu, Samson; Bury, Jonathan et al. (2003) Comparing computer-interpretable guideline models: a case-study approach. J Am Med Inform Assoc 10:52-68

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