Abstract

The long-range aim of the proposed research is to understand the role central nervous system neurotransmitter systems play in the mediation of the actions of psychotropic drugs and in the maintenance of behavior. We will focus on dopamine, norepinephrine, 5-hydroxytryptamine and gamma amino butyric acid, and their relationship to operant behavior. Feeding, drinking and locomotion will also be studied since they are important components of operant behavior. The actions of neurotransmitters will be modified by drugs and/or neurotoxins. Behavior will be measured using computer-oriented techniques. There are two broadly defined foci of the current application. First, we will attempt to identify changes in neurotransmitter systems that occur when operant behavior is modified by administration of antidepressant drugs. The goal of this research is to elucidate changes in central nervous system neurochemistry which lead to changes in behavior and which may be involved in the pathophysiology of depression. Second, we will attempt to identify the neurochemical mechanisms in the central nervous system that account for drug-behavior-environment interactions to further understand the relative roles of drugs and the environment in modifications of behavior.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
2R01MH011191-20
Application #
3374600
Study Section
(BPNA)
Project Start
1977-12-15
Project End
1988-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
20
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Bergmann, B M; Seiden, L S; Landis, C A et al. (1994) Sleep deprivation in the rat: XVIII. Regional brain levels of monoamines and their metabolites. Sleep 17:583-9
Richards, J B; Sabol, K E; Hand, T H et al. (1994) Buspirone, gepirone, ipsapirone, and zalospirone have distinct effects on the differential-reinforcement-of-low-rate 72-s schedule when compared with 5-HTP and diazepam. Psychopharmacology (Berl) 114:39-46
Marek, G J; Heffner, T G; Richards, J B et al. (1993) Effects of caffeine and PD 116,600 on the differential-reinforcement-of-low rate 72-S (DRL 72-S) schedule of reinforcement. Pharmacol Biochem Behav 45:987-90
Richards, J B; Sabol, K E; Seiden, L S (1993) Fluoxetine prevents the disruptive effects of fenfluramine on differential-reinforcement-of-low-rate 72-second schedule performance. J Pharmacol Exp Ther 267:1256-63
Richards, J B; Sabol, K E; Seiden, L S (1993) DRL interresponse-time distributions: quantification by peak deviation analysis. J Exp Anal Behav 60:361-85
Richards, J B; Seiden, L S (1991) A quantitative interresponse-time analysis of DRL performance differentiates similar effects of the antidepressant desipramine and the novel anxiolytic gepirone. J Exp Anal Behav 56:173-92
Hand, T H; Marek, G J; Seiden, L S (1991) Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity. Psychopharmacology (Berl) 105:453-8
Li, A A; Marek, G J; Hand, T H et al. (1990) Antidepressant-like effects of trazodone on a behavioral screen are mediated by trazodone, not the metabolite m-chlorophenylpiperazine. Eur J Pharmacol 177:137-44
Marek, G J; Vosmer, G; Seiden, L S (1990) Pargyline increases 6-hydroxydopamine levels in the neostriatum of methamphetamine-treated rats. Pharmacol Biochem Behav 36:187-90
Marek, G J; Li, A A; Seiden, L S (1989) Selective 5-hydroxytryptamine2 antagonists have antidepressant-like effects on differential-reinforcement-of-low-rate 72-second schedule. J Pharmacol Exp Ther 250:52-9

Showing the most recent 10 out of 25 publications