Abstract

We plan to study auditory evoked potentials in both clinical neurological disorders and animal experiments to define neural mechanisms of the generation of these potentials. In particular, we will study in experimental animals the role of pontine auditory structures in generating auditory brainstem components using discrete lesion methods. The generation of middle-latency, long-latency, and endogenous components will be examined using electrical recording and lesion methods in monkeys engaged in an auditory discrimination task. The application of auditory evoked potentials to patients with neurological disorders will be for 1) longlatency and endogenous components during the recovery from coma; 2) the effects of task complexity on endogenous components in dementing illnesses and 3) endogenous components during the catagorization of words in patients with aphasia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS011876-13
Application #
3394647
Study Section
Hearing Research Study Section (HAR)
Project Start
1977-09-01
Project End
1987-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
13
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Zaaroor, M; Starr, A (1997) Experimental facial myokymia in cat. Acta Neurol Scand 95:19-22
Patterson, J V; Pratt, H; Starr, A (1991) Event-related potential correlates of the serial position effect in short-term memory. Electroencephalogr Clin Neurophysiol 78:424-37
Zaaroor, M; Starr, A (1991) Auditory brain-stem evoked potentials in cat after kainic acid induced neuronal loss. II. Cochlear nucleus. Electroencephalogr Clin Neurophysiol 80:436-45
Zaaroor, M; Starr, A (1991) Auditory brain-stem evoked potentials in cat after kainic acid induced neuronal loss. I. Superior olivary complex. Electroencephalogr Clin Neurophysiol 80:422-35
Starr, A; Zaaroor, M (1990) Eighth nerve contributions to cat auditory brainstem responses (ABR). Hear Res 48:151-60
Lott, I T; McPherson, D; Towne, B et al. (1990) Long-term neurophysiologic outcome after neonatal extracorporeal membrane oxygenation. J Pediatr 116:343-9
Pratt, H; Michalewski, H J; Patterson, J V et al. (1989) Brain potentials in a memory-scanning task. II. Effects of aging on potentials to the probes. Electroencephalogr Clin Neurophysiol 72:507-17
McPherson, D L; Madden, J D; Payne, T F (1989) Auditory brainstem-evoked potentials in term infants born to mothers addicted to opiates. J Perinatol 9:262-7
Wada, S; Starr, A (1989) Anatomical bases of binaural interaction in auditory brain-stem responses from guinea pig. Electroencephalogr Clin Neurophysiol 72:535-44
Pratt, H; Michalewski, H J; Patterson, J V et al. (1989) Brain potentials in a memory-scanning task. III. Potentials to the items being memorized. Electroencephalogr Clin Neurophysiol 73:41-51

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