Abstract

We plan to study auditory evoked potentials (AEPs) in both clinical neurological disorders and animal experiments to define neural mechanisms of the generation of these potentials and their application to disordered brain function. In particular, we will study in experimental animals the role of cells and nerve fibers in generating far-field auditory brainstem components using specific lesion methods and in an in-vitro model system using nerve fibers passing between fluid compartments of different volumes and impedances. Long-latency AEPs related to the encoding of words and tones and their subsequent memorization will be studied in normal subjects and patients with focal hemispheric lesions to define neural correlates of language processing and auditory memory. The definition of binaural processes relevant for sound localization will be defined in middle and long-latency AEPs by the occurence of binaural interaction components and related to several psychoacoustic measures in normal subjects, patients with neurological lesions, and in children during maturation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
2R01NS011876-14
Application #
3394645
Study Section
Hearing Research Study Section (HAR)
Project Start
1977-09-01
Project End
1991-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
14
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697

  Publications

Zaaroor, M; Starr, A (1997) Experimental facial myokymia in cat. Acta Neurol Scand 95:19-22
Patterson, J V; Pratt, H; Starr, A (1991) Event-related potential correlates of the serial position effect in short-term memory. Electroencephalogr Clin Neurophysiol 78:424-37
Zaaroor, M; Starr, A (1991) Auditory brain-stem evoked potentials in cat after kainic acid induced neuronal loss. II. Cochlear nucleus. Electroencephalogr Clin Neurophysiol 80:436-45
Zaaroor, M; Starr, A (1991) Auditory brain-stem evoked potentials in cat after kainic acid induced neuronal loss. I. Superior olivary complex. Electroencephalogr Clin Neurophysiol 80:422-35
Starr, A; Zaaroor, M (1990) Eighth nerve contributions to cat auditory brainstem responses (ABR). Hear Res 48:151-60
Lott, I T; McPherson, D; Towne, B et al. (1990) Long-term neurophysiologic outcome after neonatal extracorporeal membrane oxygenation. J Pediatr 116:343-9
Pratt, H; Michalewski, H J; Patterson, J V et al. (1989) Brain potentials in a memory-scanning task. II. Effects of aging on potentials to the probes. Electroencephalogr Clin Neurophysiol 72:507-17
McPherson, D L; Madden, J D; Payne, T F (1989) Auditory brainstem-evoked potentials in term infants born to mothers addicted to opiates. J Perinatol 9:262-7
Wada, S; Starr, A (1989) Anatomical bases of binaural interaction in auditory brain-stem responses from guinea pig. Electroencephalogr Clin Neurophysiol 72:535-44
Pratt, H; Michalewski, H J; Patterson, J V et al. (1989) Brain potentials in a memory-scanning task. III. Potentials to the items being memorized. Electroencephalogr Clin Neurophysiol 73:41-51

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