Abstract

The overall purpose of this application is to refine existing techniques and to develop new methodology and technology for autoradiographic imaging of cerebral blood flow and metabolism and their interrelationships. A very high performance, low cost imaging system for quantitative analysis and three dimensional processing and display of autoradiographic images will be developed. The system will then be used for analysis of autoradiograms of cerebral blood flow and metabolism tracers in animals. Using dobule and triple label autoradiography, the kinetics of various tracers of flow and metabolism will be compared. Results of these studies will be used to evaluate the existing kinetic models, and to assess the significance and limitations of basic assumptions. The imaging system will then be interfaced to clinical imaging instruments such as gamma cameras so that the resuls of the animal studies can be directly applied to patient data.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS026657-04
Application #
3412637
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1988-12-01
Project End
1993-07-31
Budget Start
1991-12-01
Budget End
1993-07-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Trujillo, N P; Pratt, J P; Talusani, S et al. (1997) DTPA aerosol in ventilation/perfusion scintigraphy for diagnosing pulmonary embolism. J Nucl Med 38:1781-3
Lear, J L; Pratt, J P; Trujillo, N (1996) Redundant array of independent disks: practical on-line archiving of nuclear medicine image data. J Digit Imaging 9:37-8
Lear, J L; Pratt, J P; Mallet, J et al. (1994) User-definable bull's-eye database analysis. Eur J Nucl Med 21:154-7
Pratt, J P; Lear, J L (1993) Increased single-photon emission computed tomography image processing speed achieved in personal computers with memory-intensive algorithms. J Digit Imaging 6:205-12
Lear, J L; Kasliwal, R; Duryea, R A (1992) Effects of variations in the duration of diffusible-tracer infusions on calculated values of global and local cerebral blood flow. Metab Brain Dis 7:197-210
Lear, J L; Ackerman, R F (1992) Comparison of regional blood-brain transport kinetics between glucose and fluorodeoxyglucose. J Nucl Med 33:1819-24
Lear, J L (1991) Relationship between myocardial clearance rates of carbon-11-acetate-derived radiolabel and oxidative metabolism: physiologic basis and clinical significance. J Nucl Med 32:1957-60
Lear, J L; Kasliwal, R K (1991) Autoradiographic measurement of cerebral lactate transport rate constants in normal and activated conditions. J Cereb Blood Flow Metab 11:576-80
Lear, J L; Kasliwal, R K; Feyerabend, A J et al. (1991) Improved tumor imaging with radiolabeled monoclonal antibodies by plasma clearance of unbound antibody with anti-antibody column. Radiology 179:509-12
Lear, J L; Ackermann, R F (1990) Evaluation of radiolabeled acetate and fluoroacetate as potential tracers of cerebral oxidative metabolism. Metab Brain Dis 5:45-56

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