Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS032848-02
Application #
2271324
Study Section
Neurology C Study Section (NEUC)
Project Start
1995-09-30
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Stanford University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305
Dumas, Theodore C; Gillette, Todd; Ferguson, Deveroux et al. (2010) Anti-glucocorticoid gene therapy reverses the impairing effects of elevated corticosterone on spatial memory, hippocampal neuronal excitability, and synaptic plasticity. J Neurosci 30:1712-20
Zhao, Heng; Yenari, Midori A; Sapolsky, Robert M et al. (2004) Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release. Stroke 35:572-7
Dumas, T C; Powers, E C; Tarapore, P E et al. (2004) Overexpression of calbindin D(28k) in dentate gyrus granule cells alters mossy fiber presynaptic function and impairs hippocampal-dependent memory. Hippocampus 14:701-9
Roy, Madhuri; Sapolsky, Robert M (2003) The neuroprotective effects of virally-derived caspase inhibitors p35 and crmA following a necrotic insult. Neurobiol Dis 14:1-9
Roy, Madhuri; Sapolsky, Robert M (2003) The exacerbation of hippocampal excitotoxicity by glucocorticoids is not mediated by apoptosis. Neuroendocrinology 77:24-31
Roy, M; Hom, J J; Sapolsky, R M (2002) HSV-mediated delivery of virally derived anti-apoptotic genes protects the rat hippocampus from damage following excitotoxicity, but not metabolic disruption. Gene Ther 9:214-9
Gupta, A; Ho, D Y; Brooke, S et al. (2001) Neuroprotective effects of an adenoviral vector expressing the glucose transporter: a detailed description of the mediating cellular events. Brain Res 908:49-57
Yenari, M A; Minami, M; Sun, G H et al. (2001) Calbindin d28k overexpression protects striatal neurons from transient focal cerebral ischemia. Stroke 32:1028-35
Phillips, R G; Monje, M L; Giuli, L C et al. (2001) Gene therapy effectiveness differs for neuronal survival and behavioral performance. Gene Ther 8:579-85
Roy, M; Hom, J; Sapolsky, R M (2001) Neuroprotection with herpes simplex vectors expressing virally derived anti-apoptotic agents. Brain Res 901:12-22

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