Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Research Project (R01)
Project #
5R01NS033548-02
Application #
2272398
Study Section
Neurological Sciences Subcommittee 1 (NLS)
Project Start
1994-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Physiology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lee, Wenjau; Wayne, Nancy L (2004) Secretion of locally synthesized neurohormone from neurites of peptidergic neurons. J Neurochem 88:532-7
Wayne, Nancy L; Lee, Wenjau; Michel, Stephan et al. (2004) Post-afterdischarge depolarization does not stimulate prolonged neurohormone secretion but is required for activity-dependent stimulation of neurohormone biosynthesis from peptidergic neurons. Endocrinology 145:1678-84
Wayne, Nancy L; Michel, Stephan (2004) Synaptic stimulation of Aplysia peptidergic neurons can activate hormone secretion in the absence of an afterdischarge. Neurosci Lett 362:249-52
Wayne, Nancy L; Lee, Wenjau; Michel, Stephan et al. (2004) Activity-dependent regulation of neurohormone synthesis and its impact on reproductive behavior in aplysia. Biol Reprod 70:277-81
Dyer, John R; Michel, Stephan; Lee, Wenjau et al. (2003) An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation. Nat Neurosci 6:219-20
Michel, Stephan; Wayne, Nancy L (2002) Neurohormone secretion persists after post-afterdischarge membrane depolarization and cytosolic calcium elevation in peptidergic neurons in intact nervous tissue. J Neurosci 22:9063-9
Lee, Wenjau; Jones, Andrea M; Ono, Joyce K et al. (2002) Regional differences in processing of locally translated prohormone in peptidergic neurons of Aplysia californica. J Neurochem 83:1423-30
Wayne, N L; Lee, W; Kim, Y J (1999) Persistent activation of calcium-activated and calcium-independent protein kinase C in response to electrical afterdischarge from peptidergic neurons of aplysia. Brain Res 834:211-3
Wayne, N L; Kim, Y J; Yong-Montenegro, R J (1998) Seasonal fluctuations in the secretory response of neuroendocrine cells of Aplysia californica to inhibitors of protein kinase A and protein kinase C. Gen Comp Endocrinol 109:356-65
Wayne, N L; Kim, J; Lee, E (1998) Prolonged hormone secretion from neuroendocrine cells of Aplysia is independent of extracellular calcium. J Neuroendocrinol 10:529-37

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